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Microbiology and Preclinical Review of Omadacycline
Omadacycline is a novel aminomethylcycline antimicrobial and semisynthetic derivative of tetracycline. In vitro, omadacycline displays potent activity against gram-positive and many gram-negative bacteria, including methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, β-hemolytic s...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669291/ https://www.ncbi.nlm.nih.gov/pubmed/31367743 http://dx.doi.org/10.1093/cid/ciz395 |
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author | Karlowsky, James A Steenbergen, Judith Zhanel, George G |
author_facet | Karlowsky, James A Steenbergen, Judith Zhanel, George G |
author_sort | Karlowsky, James A |
collection | PubMed |
description | Omadacycline is a novel aminomethylcycline antimicrobial and semisynthetic derivative of tetracycline. In vitro, omadacycline displays potent activity against gram-positive and many gram-negative bacteria, including methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, β-hemolytic streptococci, vancomycin-resistant Enterococcus, and Enterobacteriaceae. Omadacycline is also active against atypical and anaerobic pathogens, including Legionella pneumophila, Mycoplasma spp., Ureaplasma spp., Bacteroides spp., and Clostridioides difficile. This review outlines the microbiology and preclinical studies of omadacycline, including its mechanism of action; spectrum of activity; protein binding; activity in the presence of surfactant, serum, normal, and pH-adjusted urine, or bacterial biofilms; postantibiotic effect; pharmacodynamic properties; and in vitro and in vivo efficacy. The results of in vitro and in vivo animal studies support the observations made in phase III clinical trials and the clinical development of omadacycline. |
format | Online Article Text |
id | pubmed-6669291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-66692912019-08-05 Microbiology and Preclinical Review of Omadacycline Karlowsky, James A Steenbergen, Judith Zhanel, George G Clin Infect Dis Supplement Articles Omadacycline is a novel aminomethylcycline antimicrobial and semisynthetic derivative of tetracycline. In vitro, omadacycline displays potent activity against gram-positive and many gram-negative bacteria, including methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, β-hemolytic streptococci, vancomycin-resistant Enterococcus, and Enterobacteriaceae. Omadacycline is also active against atypical and anaerobic pathogens, including Legionella pneumophila, Mycoplasma spp., Ureaplasma spp., Bacteroides spp., and Clostridioides difficile. This review outlines the microbiology and preclinical studies of omadacycline, including its mechanism of action; spectrum of activity; protein binding; activity in the presence of surfactant, serum, normal, and pH-adjusted urine, or bacterial biofilms; postantibiotic effect; pharmacodynamic properties; and in vitro and in vivo efficacy. The results of in vitro and in vivo animal studies support the observations made in phase III clinical trials and the clinical development of omadacycline. Oxford University Press 2019-08-15 2019-08-01 /pmc/articles/PMC6669291/ /pubmed/31367743 http://dx.doi.org/10.1093/cid/ciz395 Text en © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in anymedium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Supplement Articles Karlowsky, James A Steenbergen, Judith Zhanel, George G Microbiology and Preclinical Review of Omadacycline |
title | Microbiology and Preclinical Review of Omadacycline |
title_full | Microbiology and Preclinical Review of Omadacycline |
title_fullStr | Microbiology and Preclinical Review of Omadacycline |
title_full_unstemmed | Microbiology and Preclinical Review of Omadacycline |
title_short | Microbiology and Preclinical Review of Omadacycline |
title_sort | microbiology and preclinical review of omadacycline |
topic | Supplement Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669291/ https://www.ncbi.nlm.nih.gov/pubmed/31367743 http://dx.doi.org/10.1093/cid/ciz395 |
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