DIVERSet JAG Compounds Inhibit Topoisomerase II and Are Effective Against Adult and Pediatric High-Grade Gliomas

High-grade gliomas (HGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis in both adult and pediatric patients. Clinical response is compounded by resistance to standard frontline antineoplastic agents, an absence of novel therapeutics, and poor in vitro mo...

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Detalles Bibliográficos
Autores principales: Howarth, Alison, Simms, Claire, Kerai, Nitesh, Allen, Olivia, Mihajluk, Karina, Madureira, Patricia A., Sokratous, Giannis, Cragg, Simon, Lee, Sang Y., Morley, Andy D., Ashkan, Keyoumars, Cox, Paul A., Pilkington, Geoffrey J., Hill, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669375/
https://www.ncbi.nlm.nih.gov/pubmed/31374406
http://dx.doi.org/10.1016/j.tranon.2019.07.007

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