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Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’s heart tissues

Introduction: Redox interactions play a key role in radiation injury including heart diseases. In present study, we aimed to detect the possible protective role of selenium-L-methionine on infiltration of immune cells and Duox1&2 upregulation in rat’s heart tissues. Methods: In this study, 20 ra...

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Autores principales: Kolivand, Sedighe, Amini, Peyman, Saffar, Hana, Rezapoor, Saeed, Najafi, Masoud, Motevaseli, Elahe, Nouruzi, Farzad, Shabeeb, Dheyauldeen, Eleojo Musa, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669428/
https://www.ncbi.nlm.nih.gov/pubmed/31384406
http://dx.doi.org/10.15171/jcvtr.2019.21
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author Kolivand, Sedighe
Amini, Peyman
Saffar, Hana
Rezapoor, Saeed
Najafi, Masoud
Motevaseli, Elahe
Nouruzi, Farzad
Shabeeb, Dheyauldeen
Eleojo Musa, Ahmed
author_facet Kolivand, Sedighe
Amini, Peyman
Saffar, Hana
Rezapoor, Saeed
Najafi, Masoud
Motevaseli, Elahe
Nouruzi, Farzad
Shabeeb, Dheyauldeen
Eleojo Musa, Ahmed
author_sort Kolivand, Sedighe
collection PubMed
description Introduction: Redox interactions play a key role in radiation injury including heart diseases. In present study, we aimed to detect the possible protective role of selenium-L-methionine on infiltration of immune cells and Duox1&2 upregulation in rat’s heart tissues. Methods: In this study, 20 rats were divided into 4 groups (5 rats in each) namely: irradiation; irradiation plus Selenium-L-methionine; control; and Selenium-L-methionine treatment. Irradiation (15 Gy to chest) was performed using a cobalt-60 gamma ray source while 4 mg/kg of selenium-L-methionine was administered intraperitoneally. Ten weeks after irradiation, rats were sacrificed for detection of IL-4 and IL-13 cytokines, infiltration of macrophages and lymphocytes as well as the expressions of IL4Ra1, Duox1, IL13Ra2 and Duox2. Results: Results showed an increase in the level of IL-4 as well as the expressions of IL4Ra1, Duox1 and Duox2. Similarly, there was an increase in the infiltration of lymphocytes and macrophages. There was significant attenuation of all these changes following treatment with selenium-L-methionine. Conclusion: Selenium-L-methionine has the potential to protect heart tissues against radiation injury. Downregulation of pro-oxidant genes and modulation of some cytokines such as IL-4 are involved in the radioprotective effect of selenium-L-methionine on heart tissues.
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spelling pubmed-66694282019-08-05 Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’s heart tissues Kolivand, Sedighe Amini, Peyman Saffar, Hana Rezapoor, Saeed Najafi, Masoud Motevaseli, Elahe Nouruzi, Farzad Shabeeb, Dheyauldeen Eleojo Musa, Ahmed J Cardiovasc Thorac Res Original Article Introduction: Redox interactions play a key role in radiation injury including heart diseases. In present study, we aimed to detect the possible protective role of selenium-L-methionine on infiltration of immune cells and Duox1&2 upregulation in rat’s heart tissues. Methods: In this study, 20 rats were divided into 4 groups (5 rats in each) namely: irradiation; irradiation plus Selenium-L-methionine; control; and Selenium-L-methionine treatment. Irradiation (15 Gy to chest) was performed using a cobalt-60 gamma ray source while 4 mg/kg of selenium-L-methionine was administered intraperitoneally. Ten weeks after irradiation, rats were sacrificed for detection of IL-4 and IL-13 cytokines, infiltration of macrophages and lymphocytes as well as the expressions of IL4Ra1, Duox1, IL13Ra2 and Duox2. Results: Results showed an increase in the level of IL-4 as well as the expressions of IL4Ra1, Duox1 and Duox2. Similarly, there was an increase in the infiltration of lymphocytes and macrophages. There was significant attenuation of all these changes following treatment with selenium-L-methionine. Conclusion: Selenium-L-methionine has the potential to protect heart tissues against radiation injury. Downregulation of pro-oxidant genes and modulation of some cytokines such as IL-4 are involved in the radioprotective effect of selenium-L-methionine on heart tissues. Tabriz University of Medical Sciences 2019 2019-06-27 /pmc/articles/PMC6669428/ /pubmed/31384406 http://dx.doi.org/10.15171/jcvtr.2019.21 Text en © 2019 The Author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kolivand, Sedighe
Amini, Peyman
Saffar, Hana
Rezapoor, Saeed
Najafi, Masoud
Motevaseli, Elahe
Nouruzi, Farzad
Shabeeb, Dheyauldeen
Eleojo Musa, Ahmed
Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’s heart tissues
title Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’s heart tissues
title_full Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’s heart tissues
title_fullStr Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’s heart tissues
title_full_unstemmed Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’s heart tissues
title_short Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’s heart tissues
title_sort selenium-l-methionine modulates radiation injury and duox1 and duox2 upregulation in rat’s heart tissues
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669428/
https://www.ncbi.nlm.nih.gov/pubmed/31384406
http://dx.doi.org/10.15171/jcvtr.2019.21
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