Cargando…

Differential Effect of the Deletion of African Swine Fever Virus Virulence-Associated Genes in the Induction of Attenuation of the Highly Virulent Georgia Strain

African swine fever virus (ASFV) is the etiological agent of an often lethal disease of domestic pigs, African swine fever (ASF). The ASFV Georgia 2007 isolate (ASFV-G) is responsible for the current epidemic situation in Europe and Asia. Genetically modified ASFVs containing deletions of virulence-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramirez-Medina, Elizabeth, Vuono, Elizabeth, O’Donnell, Vivian, Holinka, Lauren G., Silva, Ediane, Rai, Ayushi, Pruitt, Sarah, Carrillo, Consuelo, Gladue, Douglas P., Borca, Manuel V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669436/ https://www.ncbi.nlm.nih.gov/pubmed/31269702 http://dx.doi.org/10.3390/v11070599

Ejemplares similares

Deletion of CD2-like gene from the genome of African swine fever virus strain Georgia does not attenuate virulence in swine
por: Borca, Manuel V., et al.
Publicado: (2020)

The C962R ORF of African Swine Fever Strain Georgia Is Non-Essential and Not Required for Virulence in Swine
por: Ramirez-Medina, Elizabeth., et al.
Publicado: (2020)

Deletion of the ASFV dUTPase Gene E165R from the Genome of Highly Virulent African Swine Fever Virus Georgia 2010 Does Not Affect Virus Replication or Virulence in Domestic Pigs
por: Vuono, Elizabeth A., et al.
Publicado: (2022)

Deletion of the EP296R Gene from the Genome of Highly Virulent African Swine Fever Virus Georgia 2010 Does Not Affect Virus Replication or Virulence in Domestic Pigs
por: Vuono, Elizabeth A., et al.
Publicado: (2022)

Deletion of an African Swine Fever Virus ATP-Dependent RNA Helicase QP509L from the Highly Virulent Georgia 2010 Strain Does Not Affect Replication or Virulence
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2022)

Deletion of African Swine Fever Virus Histone-like Protein, A104R from the Georgia Isolate Drastically Reduces Virus Virulence in Domestic Pigs
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2022)

X69R Is a Non-Essential Gene That, When Deleted from African Swine Fever, Does Not Affect Virulence in Swine
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2020)

Deletion of CD2-Like (CD2v) and C-Type Lectin-Like (EP153R) Genes from African Swine Fever Virus Georgia-∆9GL Abrogates Its Effectiveness as an Experimental Vaccine
por: Gladue, Douglas P., et al.
Publicado: (2020)

Development and In Vivo Evaluation of a MGF110-1L Deletion Mutant in African Swine Fever Strain Georgia
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2021)

Evaluation in Swine of a Recombinant Georgia 2010 African Swine Fever Virus Lacking the I8L Gene
por: Vuono, Elizabeth, et al.
Publicado: (2020)

Deletion of the H240R Gene in African Swine Fever Virus Partially Reduces Virus Virulence in Swine
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2023)

SERTA Domain Containing Protein 1 (SERTAD1) Interacts with Classical Swine Fever Virus Structural Glycoprotein E2, Which Is Involved in Virus Virulence in Swine
por: Vuono, Elizabeth A., et al.
Publicado: (2020)

ASFV Gene A151R Is Involved in the Process of Virulence in Domestic Swine
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2022)

Identification of a Continuously Stable and Commercially Available Cell Line for the Identification of Infectious African Swine Fever Virus in Clinical Samples
por: Rai, Ayushi, et al.
Publicado: (2020)

The MGF360-16R ORF of African Swine Fever Virus Strain Georgia Encodes for a Nonessential Gene That Interacts with Host Proteins SERTAD3 and SDCBP
por: Ramírez-Medina, Elizabeth, et al.
Publicado: (2020)

Evaluation in Swine of a Recombinant African Swine Fever Virus Lacking the MGF-360-1L Gene
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2020)

Evaluation of an ASFV RNA Helicase Gene A859L for Virus Replication and Swine Virulence
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2021)

Swine Host Protein Coiled-Coil Domain-Containing 115 (CCDC115) Interacts with Classical Swine Fever Virus Structural Glycoprotein E2 during Virus Replication
por: Vuono, Elizabeth A., et al.
Publicado: (2020)

Evaluation of the Function of the ASFV KP177R Gene, Encoding for Structural Protein p22, in the Process of Virus Replication and in Swine Virulence
por: Vuono, Elizabeth A., et al.
Publicado: (2021)

ASFV-G-∆I177L as an Effective Oral Nasal Vaccine against the Eurasia Strain of Africa Swine Fever
por: Borca, Manuel V., et al.
Publicado: (2021)

Classical Swine Fever Virus Structural Glycoprotein E2 Interacts with Host Protein ACADM during the Virus Infectious Cycle
por: Vuono, Elizabeth, et al.
Publicado: (2023)

Evaluation of the Deletion of the African Swine Fever Virus Gene O174L from the Genome of the Georgia Isolate
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2023)

Full genome sequence for the African swine fever virus outbreak in the Dominican Republic in 1980
por: Spinard, Edward, et al.
Publicado: (2023)

Evaluation of the Function of ASFV Gene E66L in the Process of Virus Replication and Virulence in Swine
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2023)

Complete Structural Predictions of the Proteome of African Swine Fever Virus Strain Georgia 2007
por: Spinard, Edward, et al.
Publicado: (2022)

Development Real-Time PCR Assays to Genetically Differentiate Vaccinated Pigs From Infected Pigs With the Eurasian Strain of African Swine Fever Virus
por: Velazquez-Salinas, Lauro, et al.
Publicado: (2021)

African Swine Fever Vaccine Candidate ASFV-G-ΔI177L Produced in the Swine Macrophage-Derived Cell Line IPKM Remains Genetically Stable and Protective against Homologous Virulent Challenge
por: Borca, Manuel V., et al.
Publicado: (2023)

Interaction of Structural Glycoprotein E2 of Classical Swine Fever Virus with Protein Phosphatase 1 Catalytic Subunit Beta (PPP1CB)
por: Vuono, Elizabeth A., et al.
Publicado: (2019)

ASF Vaccine Candidate ASFV-G-∆I177L Does Not Exhibit Residual Virulence in Long-Term Clinical Studies
por: Borca, Manuel V., et al.
Publicado: (2023)

A Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Protect Pigs against a Virulent CSFV Challenge
por: Silva, Ediane, et al.
Publicado: (2023)

The Presence of Virus Neutralizing Antibodies Is Highly Associated with Protection against Virulent Challenge in Domestic Pigs Immunized with ASFV live Attenuated Vaccine Candidates
por: Silva, Ediane B., et al.
Publicado: (2022)

Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum
por: Gladue, Douglas P., et al.
Publicado: (2018)

Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages
por: Zhu, James J., et al.
Publicado: (2019)

Early protection events in swine immunized with an experimental live attenuated classical swine fever marker vaccine, FlagT4G
por: Holinka, Lauren G., et al.
Publicado: (2017)

Experimental Infection of Domestic Pigs with an African Swine Fever Virus Field Strain Isolated in 2021 from the Dominican Republic
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2022)

Association of the Host Immune Response with Protection Using a Live Attenuated African Swine Fever Virus Model
por: Carlson, Jolene, et al.
Publicado: (2016)

The 2022 Outbreaks of African Swine Fever Virus Demonstrate the First Report of Genotype II in Ghana
por: Spinard, Edward, et al.
Publicado: (2023)

Development of a fluorescent ASFV strain that retains the ability to cause disease in swine
por: Borca, Manuel V., et al.
Publicado: (2017)

CRISPR-Cas9, a tool to efficiently increase the development of recombinant African swine fever viruses
por: Borca, Manuel V., et al.
Publicado: (2018)

Serum Neutralizing and Enhancing Effects on African Swine Fever Virus Infectivity in Adherent Pig PBMC
por: Canter, Jessica A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6vd8iqbg78d0oclsh16i8scd0t