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The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future

Due to their large geographic distribution and potential high mortality rates in human infections, hantaviruses constitute a worldwide threat to public health. As such, they have been the subject of a large array of clinical, virological and eco-evolutionary studies. Many experiments have been condu...

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Autores principales: Madrières, Sarah, Castel, Guillaume, Murri, Séverine, Vulin, Johann, Marianneau, Philippe, Charbonnel, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669540/
https://www.ncbi.nlm.nih.gov/pubmed/31331096
http://dx.doi.org/10.3390/v11070664
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author Madrières, Sarah
Castel, Guillaume
Murri, Séverine
Vulin, Johann
Marianneau, Philippe
Charbonnel, Nathalie
author_facet Madrières, Sarah
Castel, Guillaume
Murri, Séverine
Vulin, Johann
Marianneau, Philippe
Charbonnel, Nathalie
author_sort Madrières, Sarah
collection PubMed
description Due to their large geographic distribution and potential high mortality rates in human infections, hantaviruses constitute a worldwide threat to public health. As such, they have been the subject of a large array of clinical, virological and eco-evolutionary studies. Many experiments have been conducted in vitro or on animal models to identify the mechanisms leading to pathogenesis in humans and to develop treatments of hantavirus diseases. Experimental research has also been dedicated to the understanding of the relationship between hantaviruses and their reservoirs. However, these studies remain too scarce considering the diversity of hantavirus/reservoir pairs identified, and the wide range of issues that need to be addressed. In this review, we present a synthesis of the experimental studies that have been conducted on hantaviruses and their reservoirs. We aim at summarizing the knowledge gathered from this research, and to emphasize the gaps that need to be filled. Despite the many difficulties encountered to carry hantavirus experiments, we advocate for the need of such studies in the future, at the interface of evolutionary ecology and virology. They are critical to address emerging areas of research, including hantavirus evolution and the epidemiological consequences of individual variation in infection outcomes.
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spelling pubmed-66695402019-08-08 The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future Madrières, Sarah Castel, Guillaume Murri, Séverine Vulin, Johann Marianneau, Philippe Charbonnel, Nathalie Viruses Review Due to their large geographic distribution and potential high mortality rates in human infections, hantaviruses constitute a worldwide threat to public health. As such, they have been the subject of a large array of clinical, virological and eco-evolutionary studies. Many experiments have been conducted in vitro or on animal models to identify the mechanisms leading to pathogenesis in humans and to develop treatments of hantavirus diseases. Experimental research has also been dedicated to the understanding of the relationship between hantaviruses and their reservoirs. However, these studies remain too scarce considering the diversity of hantavirus/reservoir pairs identified, and the wide range of issues that need to be addressed. In this review, we present a synthesis of the experimental studies that have been conducted on hantaviruses and their reservoirs. We aim at summarizing the knowledge gathered from this research, and to emphasize the gaps that need to be filled. Despite the many difficulties encountered to carry hantavirus experiments, we advocate for the need of such studies in the future, at the interface of evolutionary ecology and virology. They are critical to address emerging areas of research, including hantavirus evolution and the epidemiological consequences of individual variation in infection outcomes. MDPI 2019-07-19 /pmc/articles/PMC6669540/ /pubmed/31331096 http://dx.doi.org/10.3390/v11070664 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Madrières, Sarah
Castel, Guillaume
Murri, Séverine
Vulin, Johann
Marianneau, Philippe
Charbonnel, Nathalie
The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future
title The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future
title_full The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future
title_fullStr The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future
title_full_unstemmed The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future
title_short The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future
title_sort needs for developing experiments on reservoirs in hantavirus research: accomplishments, challenges and promises for the future
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669540/
https://www.ncbi.nlm.nih.gov/pubmed/31331096
http://dx.doi.org/10.3390/v11070664
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