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Preparation and Performance of Antibacterial Polyvinyl Alcohol/Polyethylene Glycol/Chitosan Hydrogels Containing Silver Chloride Nanoparticles via One-step Method

Silver nano-particles (AgNPs)-filled antibacterial materials have been widely employed in the fields of biology and biomedicine. However, AgNPs have shown obvious cytotoxicity. Hence it is more reasonable to use silver chloride nanoparticles (AgCl NPs) to prepare antibacterial materials due to the s...

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Detalles Bibliográficos
Autores principales: Li, Gang, Zhang, Daohai, Qin, Shuhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669572/
https://www.ncbi.nlm.nih.gov/pubmed/31277280
http://dx.doi.org/10.3390/nano9070972
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author Li, Gang
Zhang, Daohai
Qin, Shuhao
author_facet Li, Gang
Zhang, Daohai
Qin, Shuhao
author_sort Li, Gang
collection PubMed
description Silver nano-particles (AgNPs)-filled antibacterial materials have been widely employed in the fields of biology and biomedicine. However, AgNPs have shown obvious cytotoxicity. Hence it is more reasonable to use silver chloride nanoparticles (AgCl NPs) to prepare antibacterial materials due to the slow release of silver ions created by AgCl NPs formed in the chitosan. In this experiment, a useful antibacterial hydrogel for skin repairation was prepared by exploring the relationship between AgCl NPs and cytotoxicity. It is worth noting that the crosslinked network structure was successfully obtained in an antibacterial AgCl/PVA (Polyvinyl alcohol)/PEG (Polyethylene glycol)/CS (Chitosan) hydrogel materials by the hydrothermal method. In detail, the dynamic particle size distribution of AgCl NPs was relatively uniform, which is analyzed by a dynamic light scattering (DLS). The internal structure of the lyophilized hydrogel showed obvious porous structure, indicating that the hydrogel had high water content. The result of X-ray photoelectron spectroscopy (XPS) confirmed the existence of a silver element. The release concentration of silver ions was analyzed by inductively coupled plasma (ICP) to study the effect of silver ions release concentration on the antibacterial activity and cytotoxicity of hydrogel. The results show that the lower concentration of silver ions can make the hydrogel have good antibacterial activity and low cytotoxicity. The bacteriostatic rate of the antibacterial hydrogel was over 90%. Simultaneously, the mechanical properties test shows that the hydrogel has good mechanical properties, which can be widely used as an antibacterial material.
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spelling pubmed-66695722019-08-08 Preparation and Performance of Antibacterial Polyvinyl Alcohol/Polyethylene Glycol/Chitosan Hydrogels Containing Silver Chloride Nanoparticles via One-step Method Li, Gang Zhang, Daohai Qin, Shuhao Nanomaterials (Basel) Article Silver nano-particles (AgNPs)-filled antibacterial materials have been widely employed in the fields of biology and biomedicine. However, AgNPs have shown obvious cytotoxicity. Hence it is more reasonable to use silver chloride nanoparticles (AgCl NPs) to prepare antibacterial materials due to the slow release of silver ions created by AgCl NPs formed in the chitosan. In this experiment, a useful antibacterial hydrogel for skin repairation was prepared by exploring the relationship between AgCl NPs and cytotoxicity. It is worth noting that the crosslinked network structure was successfully obtained in an antibacterial AgCl/PVA (Polyvinyl alcohol)/PEG (Polyethylene glycol)/CS (Chitosan) hydrogel materials by the hydrothermal method. In detail, the dynamic particle size distribution of AgCl NPs was relatively uniform, which is analyzed by a dynamic light scattering (DLS). The internal structure of the lyophilized hydrogel showed obvious porous structure, indicating that the hydrogel had high water content. The result of X-ray photoelectron spectroscopy (XPS) confirmed the existence of a silver element. The release concentration of silver ions was analyzed by inductively coupled plasma (ICP) to study the effect of silver ions release concentration on the antibacterial activity and cytotoxicity of hydrogel. The results show that the lower concentration of silver ions can make the hydrogel have good antibacterial activity and low cytotoxicity. The bacteriostatic rate of the antibacterial hydrogel was over 90%. Simultaneously, the mechanical properties test shows that the hydrogel has good mechanical properties, which can be widely used as an antibacterial material. MDPI 2019-07-03 /pmc/articles/PMC6669572/ /pubmed/31277280 http://dx.doi.org/10.3390/nano9070972 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Gang
Zhang, Daohai
Qin, Shuhao
Preparation and Performance of Antibacterial Polyvinyl Alcohol/Polyethylene Glycol/Chitosan Hydrogels Containing Silver Chloride Nanoparticles via One-step Method
title Preparation and Performance of Antibacterial Polyvinyl Alcohol/Polyethylene Glycol/Chitosan Hydrogels Containing Silver Chloride Nanoparticles via One-step Method
title_full Preparation and Performance of Antibacterial Polyvinyl Alcohol/Polyethylene Glycol/Chitosan Hydrogels Containing Silver Chloride Nanoparticles via One-step Method
title_fullStr Preparation and Performance of Antibacterial Polyvinyl Alcohol/Polyethylene Glycol/Chitosan Hydrogels Containing Silver Chloride Nanoparticles via One-step Method
title_full_unstemmed Preparation and Performance of Antibacterial Polyvinyl Alcohol/Polyethylene Glycol/Chitosan Hydrogels Containing Silver Chloride Nanoparticles via One-step Method
title_short Preparation and Performance of Antibacterial Polyvinyl Alcohol/Polyethylene Glycol/Chitosan Hydrogels Containing Silver Chloride Nanoparticles via One-step Method
title_sort preparation and performance of antibacterial polyvinyl alcohol/polyethylene glycol/chitosan hydrogels containing silver chloride nanoparticles via one-step method
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669572/
https://www.ncbi.nlm.nih.gov/pubmed/31277280
http://dx.doi.org/10.3390/nano9070972
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