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The Impact of Surface Functionalization on the Biophysical Properties of Silver Nanoparticles
Among metal-based nanoparticles, silver nanoparticles (AgNPs) are particularly appealing because of their stability, functionality, and documented antimicrobial properties. AgNPs also offer the possibility of different surface modifications. In this work, we functionalized AgNPs with thiobarbituric...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669631/ https://www.ncbi.nlm.nih.gov/pubmed/31277307 http://dx.doi.org/10.3390/nano9070973 |
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author | Borowik, Agnieszka Butowska, Kamila Konkel, Kinga Banasiuk, Rafał Derewonko, Natalia Wyrzykowski, Dariusz Davydenko, Mykola Cherepanov, Vsevolod Styopkin, Viktor Prylutskyy, Yuriy Pohl, Paweł Krolicka, Aleksandra Piosik, Jacek |
author_facet | Borowik, Agnieszka Butowska, Kamila Konkel, Kinga Banasiuk, Rafał Derewonko, Natalia Wyrzykowski, Dariusz Davydenko, Mykola Cherepanov, Vsevolod Styopkin, Viktor Prylutskyy, Yuriy Pohl, Paweł Krolicka, Aleksandra Piosik, Jacek |
author_sort | Borowik, Agnieszka |
collection | PubMed |
description | Among metal-based nanoparticles, silver nanoparticles (AgNPs) are particularly appealing because of their stability, functionality, and documented antimicrobial properties. AgNPs also offer the possibility of different surface modifications. In this work, we functionalized AgNPs with thiobarbituric acid or 11-mercaptoundecanoic acid residues to improve the nanoparticles’ biological activities. Subsequently, we assessed the physicochemical properties of newly synthesized AgNPs using a wide range of biophysical methodologies, including UV/vis and fluorescence spectroscopy, atomic force and scanning electron microscopy, and dynamic light scattering and isothermal titration calorimetry. Next, we examined the effect of nanoparticles functionalization on AgNPs mutagenicity and toxicity. Our study revealed that AgNPs’ surface modification affects nanoparticles aggregation, and also impacts nanoparticles’ interaction with model acridine mutagen ICR-191. AgNPs coated with MUA showed the most interesting interactions with tested ICR-191, slightly modulating its toxicity properties by decreasing the viability in treated cells. |
format | Online Article Text |
id | pubmed-6669631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66696312019-08-08 The Impact of Surface Functionalization on the Biophysical Properties of Silver Nanoparticles Borowik, Agnieszka Butowska, Kamila Konkel, Kinga Banasiuk, Rafał Derewonko, Natalia Wyrzykowski, Dariusz Davydenko, Mykola Cherepanov, Vsevolod Styopkin, Viktor Prylutskyy, Yuriy Pohl, Paweł Krolicka, Aleksandra Piosik, Jacek Nanomaterials (Basel) Article Among metal-based nanoparticles, silver nanoparticles (AgNPs) are particularly appealing because of their stability, functionality, and documented antimicrobial properties. AgNPs also offer the possibility of different surface modifications. In this work, we functionalized AgNPs with thiobarbituric acid or 11-mercaptoundecanoic acid residues to improve the nanoparticles’ biological activities. Subsequently, we assessed the physicochemical properties of newly synthesized AgNPs using a wide range of biophysical methodologies, including UV/vis and fluorescence spectroscopy, atomic force and scanning electron microscopy, and dynamic light scattering and isothermal titration calorimetry. Next, we examined the effect of nanoparticles functionalization on AgNPs mutagenicity and toxicity. Our study revealed that AgNPs’ surface modification affects nanoparticles aggregation, and also impacts nanoparticles’ interaction with model acridine mutagen ICR-191. AgNPs coated with MUA showed the most interesting interactions with tested ICR-191, slightly modulating its toxicity properties by decreasing the viability in treated cells. MDPI 2019-07-03 /pmc/articles/PMC6669631/ /pubmed/31277307 http://dx.doi.org/10.3390/nano9070973 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Borowik, Agnieszka Butowska, Kamila Konkel, Kinga Banasiuk, Rafał Derewonko, Natalia Wyrzykowski, Dariusz Davydenko, Mykola Cherepanov, Vsevolod Styopkin, Viktor Prylutskyy, Yuriy Pohl, Paweł Krolicka, Aleksandra Piosik, Jacek The Impact of Surface Functionalization on the Biophysical Properties of Silver Nanoparticles |
title | The Impact of Surface Functionalization on the Biophysical Properties of Silver Nanoparticles |
title_full | The Impact of Surface Functionalization on the Biophysical Properties of Silver Nanoparticles |
title_fullStr | The Impact of Surface Functionalization on the Biophysical Properties of Silver Nanoparticles |
title_full_unstemmed | The Impact of Surface Functionalization on the Biophysical Properties of Silver Nanoparticles |
title_short | The Impact of Surface Functionalization on the Biophysical Properties of Silver Nanoparticles |
title_sort | impact of surface functionalization on the biophysical properties of silver nanoparticles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669631/ https://www.ncbi.nlm.nih.gov/pubmed/31277307 http://dx.doi.org/10.3390/nano9070973 |
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