The Optimal Concentration of Formaldehyde is Key to Stabilizing the Pre-Fusion Conformation of Respiratory Syncytial Virus Fusion Protein

Background: To date, there is no licensed vaccine available to prevent respiratory syncytial virus (RSV) infection. The valuable pre-fusion conformation of the fusion protein (pre-F) is prone to lose high neutralizing antigenic sites. The goals of this study were to stabilize pre-F protein by fixati...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Zhang, Lu-Jing, Zhan, Lu-Ting, Zhao, Min, Wu, Guang-Hua, Si, Jun-Yu, Chen, Li, Lin, Xue, Sun, Yong-Peng, Lin, Min, Yu, Chao, Fang, Mu-Jin, Wang, Ying-Bin, Zheng, Zi-Zheng, Xia, Ning-Shao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669674/
https://www.ncbi.nlm.nih.gov/pubmed/31288455
http://dx.doi.org/10.3390/v11070628

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