New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015

The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1–21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR–ESI–MS. Their absolute configurations...

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Autores principales: Pang, Xiaoyan, Cai, Guodi, Lin, Xiuping, Salendra, Limbadri, Zhou, Xuefeng, Yang, Bin, Wang, Junjian, Wang, Junfeng, Xu, Shihai, Liu, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669684/
https://www.ncbi.nlm.nih.gov/pubmed/31284448
http://dx.doi.org/10.3390/md17070398
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author Pang, Xiaoyan
Cai, Guodi
Lin, Xiuping
Salendra, Limbadri
Zhou, Xuefeng
Yang, Bin
Wang, Junjian
Wang, Junfeng
Xu, Shihai
Liu, Yonghong
author_facet Pang, Xiaoyan
Cai, Guodi
Lin, Xiuping
Salendra, Limbadri
Zhou, Xuefeng
Yang, Bin
Wang, Junjian
Wang, Junfeng
Xu, Shihai
Liu, Yonghong
author_sort Pang, Xiaoyan
collection PubMed
description The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1–21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR–ESI–MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC(50) value of 5.19 μM. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 μg/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 μg/mL.
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spelling pubmed-66696842019-08-08 New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015 Pang, Xiaoyan Cai, Guodi Lin, Xiuping Salendra, Limbadri Zhou, Xuefeng Yang, Bin Wang, Junjian Wang, Junfeng Xu, Shihai Liu, Yonghong Mar Drugs Article The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1–21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR–ESI–MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC(50) value of 5.19 μM. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 μg/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 μg/mL. MDPI 2019-07-05 /pmc/articles/PMC6669684/ /pubmed/31284448 http://dx.doi.org/10.3390/md17070398 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pang, Xiaoyan
Cai, Guodi
Lin, Xiuping
Salendra, Limbadri
Zhou, Xuefeng
Yang, Bin
Wang, Junjian
Wang, Junfeng
Xu, Shihai
Liu, Yonghong
New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015
title New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015
title_full New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015
title_fullStr New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015
title_full_unstemmed New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015
title_short New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015
title_sort new alkaloids and polyketides from the marine sponge-derived fungus penicillium sp. scsio41015
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669684/
https://www.ncbi.nlm.nih.gov/pubmed/31284448
http://dx.doi.org/10.3390/md17070398
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