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A Lineage of Begomoviruses Encode Rep and AC4 Proteins of Enigmatic Ancestry: Hints on the Evolution of Geminiviruses in the New World
The begomoviruses (BGVs) are plant pathogens that evolved in the Old World during the Cretaceous and arrived to the New World (NW) in the Cenozoic era. A subgroup of NW BGVs, the “Squash leaf curl virus (SLCV) lineage” (S-Lin), includes viruses with unique characteristics. To get clues on the evolut...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669703/ https://www.ncbi.nlm.nih.gov/pubmed/31337020 http://dx.doi.org/10.3390/v11070644 |
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author | Torres-Herrera, Sandra Iliana Romero-Osorio, Angélica Moreno-Valenzuela, Oscar Pastor-Palacios, Guillermo Cardenas-Conejo, Yair Ramírez-Prado, Jorge H. Riego-Ruiz, Lina Minero-García, Yereni Ambriz-Granados, Salvador Argüello-Astorga, Gerardo R. |
author_facet | Torres-Herrera, Sandra Iliana Romero-Osorio, Angélica Moreno-Valenzuela, Oscar Pastor-Palacios, Guillermo Cardenas-Conejo, Yair Ramírez-Prado, Jorge H. Riego-Ruiz, Lina Minero-García, Yereni Ambriz-Granados, Salvador Argüello-Astorga, Gerardo R. |
author_sort | Torres-Herrera, Sandra Iliana |
collection | PubMed |
description | The begomoviruses (BGVs) are plant pathogens that evolved in the Old World during the Cretaceous and arrived to the New World (NW) in the Cenozoic era. A subgroup of NW BGVs, the “Squash leaf curl virus (SLCV) lineage” (S-Lin), includes viruses with unique characteristics. To get clues on the evolutionary origin of this lineage, a search for divergent members was undertaken. Four novel BGVs were characterized, including one that is basal to the group. Comparative analyses led to discover a ~670 bp genome module that is nearly exclusive of this lineage, encompassing the replication origin, the AC4 gene, and 480 bp of the Rep gene. A similar DNA module was found in two curtoviruses, hence suggesting that the S-Lin ancestor acquired its distinctive genomic segment by recombination with a curtovirus. This hypothesis was definitely disproved by an in-depth sequence analysis. The search for homologs of S-Lin Rep uncover the common origin of Rep proteins encoded by diverse Geminiviridae genera and viral “fossils” integrated at plant genomes. In contrast, no homolog of S-Lin Rep was found in public databases. Consequently, it was concluded that the SLCV clade ancestor evolved by a recombination event between a primitive NW BGV and a virus from a hitherto unknown lineage. |
format | Online Article Text |
id | pubmed-6669703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66697032019-08-08 A Lineage of Begomoviruses Encode Rep and AC4 Proteins of Enigmatic Ancestry: Hints on the Evolution of Geminiviruses in the New World Torres-Herrera, Sandra Iliana Romero-Osorio, Angélica Moreno-Valenzuela, Oscar Pastor-Palacios, Guillermo Cardenas-Conejo, Yair Ramírez-Prado, Jorge H. Riego-Ruiz, Lina Minero-García, Yereni Ambriz-Granados, Salvador Argüello-Astorga, Gerardo R. Viruses Article The begomoviruses (BGVs) are plant pathogens that evolved in the Old World during the Cretaceous and arrived to the New World (NW) in the Cenozoic era. A subgroup of NW BGVs, the “Squash leaf curl virus (SLCV) lineage” (S-Lin), includes viruses with unique characteristics. To get clues on the evolutionary origin of this lineage, a search for divergent members was undertaken. Four novel BGVs were characterized, including one that is basal to the group. Comparative analyses led to discover a ~670 bp genome module that is nearly exclusive of this lineage, encompassing the replication origin, the AC4 gene, and 480 bp of the Rep gene. A similar DNA module was found in two curtoviruses, hence suggesting that the S-Lin ancestor acquired its distinctive genomic segment by recombination with a curtovirus. This hypothesis was definitely disproved by an in-depth sequence analysis. The search for homologs of S-Lin Rep uncover the common origin of Rep proteins encoded by diverse Geminiviridae genera and viral “fossils” integrated at plant genomes. In contrast, no homolog of S-Lin Rep was found in public databases. Consequently, it was concluded that the SLCV clade ancestor evolved by a recombination event between a primitive NW BGV and a virus from a hitherto unknown lineage. MDPI 2019-07-13 /pmc/articles/PMC6669703/ /pubmed/31337020 http://dx.doi.org/10.3390/v11070644 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Torres-Herrera, Sandra Iliana Romero-Osorio, Angélica Moreno-Valenzuela, Oscar Pastor-Palacios, Guillermo Cardenas-Conejo, Yair Ramírez-Prado, Jorge H. Riego-Ruiz, Lina Minero-García, Yereni Ambriz-Granados, Salvador Argüello-Astorga, Gerardo R. A Lineage of Begomoviruses Encode Rep and AC4 Proteins of Enigmatic Ancestry: Hints on the Evolution of Geminiviruses in the New World |
title | A Lineage of Begomoviruses Encode Rep and AC4 Proteins of Enigmatic Ancestry: Hints on the Evolution of Geminiviruses in the New World |
title_full | A Lineage of Begomoviruses Encode Rep and AC4 Proteins of Enigmatic Ancestry: Hints on the Evolution of Geminiviruses in the New World |
title_fullStr | A Lineage of Begomoviruses Encode Rep and AC4 Proteins of Enigmatic Ancestry: Hints on the Evolution of Geminiviruses in the New World |
title_full_unstemmed | A Lineage of Begomoviruses Encode Rep and AC4 Proteins of Enigmatic Ancestry: Hints on the Evolution of Geminiviruses in the New World |
title_short | A Lineage of Begomoviruses Encode Rep and AC4 Proteins of Enigmatic Ancestry: Hints on the Evolution of Geminiviruses in the New World |
title_sort | lineage of begomoviruses encode rep and ac4 proteins of enigmatic ancestry: hints on the evolution of geminiviruses in the new world |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669703/ https://www.ncbi.nlm.nih.gov/pubmed/31337020 http://dx.doi.org/10.3390/v11070644 |
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