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The ADP-Ribosylating Toxins of Salmonella

A number of pathogenic bacteria utilize toxins to mediate disease in a susceptible host. The foodborne pathogen Salmonella is one of the most important and well-studied bacterial pathogens. Recently, whole genome sequence characterizations revealed the presence of multiple novel ADP-ribosylating tox...

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Autores principales: Cheng, Rachel A., Wiedmann, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669713/
https://www.ncbi.nlm.nih.gov/pubmed/31315299
http://dx.doi.org/10.3390/toxins11070416
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author Cheng, Rachel A.
Wiedmann, Martin
author_facet Cheng, Rachel A.
Wiedmann, Martin
author_sort Cheng, Rachel A.
collection PubMed
description A number of pathogenic bacteria utilize toxins to mediate disease in a susceptible host. The foodborne pathogen Salmonella is one of the most important and well-studied bacterial pathogens. Recently, whole genome sequence characterizations revealed the presence of multiple novel ADP-ribosylating toxins encoded by a variety of Salmonella serovars. In this review, we discuss both the classical (SpvB) and novel (typhoid toxin, ArtAB, and SboC/SeoC) ADP-ribosylating toxins of Salmonella, including the structure and function of these toxins and our current understanding of their contributions to virulence.
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spelling pubmed-66697132019-08-08 The ADP-Ribosylating Toxins of Salmonella Cheng, Rachel A. Wiedmann, Martin Toxins (Basel) Review A number of pathogenic bacteria utilize toxins to mediate disease in a susceptible host. The foodborne pathogen Salmonella is one of the most important and well-studied bacterial pathogens. Recently, whole genome sequence characterizations revealed the presence of multiple novel ADP-ribosylating toxins encoded by a variety of Salmonella serovars. In this review, we discuss both the classical (SpvB) and novel (typhoid toxin, ArtAB, and SboC/SeoC) ADP-ribosylating toxins of Salmonella, including the structure and function of these toxins and our current understanding of their contributions to virulence. MDPI 2019-07-16 /pmc/articles/PMC6669713/ /pubmed/31315299 http://dx.doi.org/10.3390/toxins11070416 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cheng, Rachel A.
Wiedmann, Martin
The ADP-Ribosylating Toxins of Salmonella
title The ADP-Ribosylating Toxins of Salmonella
title_full The ADP-Ribosylating Toxins of Salmonella
title_fullStr The ADP-Ribosylating Toxins of Salmonella
title_full_unstemmed The ADP-Ribosylating Toxins of Salmonella
title_short The ADP-Ribosylating Toxins of Salmonella
title_sort adp-ribosylating toxins of salmonella
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669713/
https://www.ncbi.nlm.nih.gov/pubmed/31315299
http://dx.doi.org/10.3390/toxins11070416
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