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Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses
Andes virus (ANDV) and Sin Nombre virus (SNV) are the main causative agents responsible for hantavirus cardiopulmonary syndrome (HCPS) in the Americas. HCPS is a severe respiratory disease with a high fatality rate for which there are no approved therapeutics or vaccines available. Some vaccine appr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669828/ https://www.ncbi.nlm.nih.gov/pubmed/31337019 http://dx.doi.org/10.3390/v11070645 |
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author | Warner, Bryce M Stein, Derek R Jangra, Rohit K Slough, Megan M Sroga, Patrycja Sloan, Angela Frost, Kathy L Booth, Stephanie Chandran, Kartik Safronetz, David |
author_facet | Warner, Bryce M Stein, Derek R Jangra, Rohit K Slough, Megan M Sroga, Patrycja Sloan, Angela Frost, Kathy L Booth, Stephanie Chandran, Kartik Safronetz, David |
author_sort | Warner, Bryce M |
collection | PubMed |
description | Andes virus (ANDV) and Sin Nombre virus (SNV) are the main causative agents responsible for hantavirus cardiopulmonary syndrome (HCPS) in the Americas. HCPS is a severe respiratory disease with a high fatality rate for which there are no approved therapeutics or vaccines available. Some vaccine approaches for HCPS have been tested in preclinical models, but none have been tested in infectious models in regard to their ability to protect against multiple species of HCPS-causing viruses. Here, we utilize recombinant vesicular stomatitis virus-based (VSV) vaccines for Andes virus (ANDV) and Sin Nombre virus (SNV) and assess their ability to provide cross-protection in infectious challenge models. We show that, while both rVSVΔG/ANDVGPC and rVSVΔG/SNVGPC display attenuated growth as compared to wild type VSV, each vaccine is able to induce a cross-reactive antibody response. Both vaccines protected against both homologous and heterologous challenge with ANDV and SNV and prevented HCPS in a lethal ANDV challenge model. This study provides evidence that the development of a single vaccine against HCPS-causing hantaviruses could provide protection against multiple agents. |
format | Online Article Text |
id | pubmed-6669828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66698282019-08-08 Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses Warner, Bryce M Stein, Derek R Jangra, Rohit K Slough, Megan M Sroga, Patrycja Sloan, Angela Frost, Kathy L Booth, Stephanie Chandran, Kartik Safronetz, David Viruses Article Andes virus (ANDV) and Sin Nombre virus (SNV) are the main causative agents responsible for hantavirus cardiopulmonary syndrome (HCPS) in the Americas. HCPS is a severe respiratory disease with a high fatality rate for which there are no approved therapeutics or vaccines available. Some vaccine approaches for HCPS have been tested in preclinical models, but none have been tested in infectious models in regard to their ability to protect against multiple species of HCPS-causing viruses. Here, we utilize recombinant vesicular stomatitis virus-based (VSV) vaccines for Andes virus (ANDV) and Sin Nombre virus (SNV) and assess their ability to provide cross-protection in infectious challenge models. We show that, while both rVSVΔG/ANDVGPC and rVSVΔG/SNVGPC display attenuated growth as compared to wild type VSV, each vaccine is able to induce a cross-reactive antibody response. Both vaccines protected against both homologous and heterologous challenge with ANDV and SNV and prevented HCPS in a lethal ANDV challenge model. This study provides evidence that the development of a single vaccine against HCPS-causing hantaviruses could provide protection against multiple agents. MDPI 2019-07-13 /pmc/articles/PMC6669828/ /pubmed/31337019 http://dx.doi.org/10.3390/v11070645 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Warner, Bryce M Stein, Derek R Jangra, Rohit K Slough, Megan M Sroga, Patrycja Sloan, Angela Frost, Kathy L Booth, Stephanie Chandran, Kartik Safronetz, David Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses |
title | Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses |
title_full | Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses |
title_fullStr | Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses |
title_full_unstemmed | Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses |
title_short | Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses |
title_sort | vesicular stomatitis virus-based vaccines provide cross-protection against andes and sin nombre viruses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669828/ https://www.ncbi.nlm.nih.gov/pubmed/31337019 http://dx.doi.org/10.3390/v11070645 |
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