Cargando…

Homology Modelling and Molecular Docking Studies of Selected Substituted Benzo[d]imidazol-1-yl)methyl)benzimidamide Scaffolds on Plasmodium falciparum Adenylosuccinate Lyase Receptor

Plasmodium falciparum adenylosuccinate lyase (PfADSL) is an important enzyme in purine metabolism. Although several benzimidazole derivatives have been commercially developed into drugs, the template design as inhibitor against PfADSL has not been fully explored. This study aims to model the 3-dimen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oduselu, Gbolahan O, Ajani, Olayinka O, Ajamma, Yvonne U, Brors, Benedikt, Adebiyi, Ezekiel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2019
Materias:	Computational Modeling Protein Structures & Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669854/ https://www.ncbi.nlm.nih.gov/pubmed/31391779 http://dx.doi.org/10.1177/1177932219865533

Ejemplares similares

Adenylosuccinate lyase deficiency
por: Jurecka, Agnieszka, et al.
Publicado: (2014)

Recent advances in functionalized quinoline scaffolds and hybrids—Exceptional pharmacophore in therapeutic medicine
por: Elebiju, Oluwadunni F., et al.
Publicado: (2023)

Synthesis, in silico and in vitro antimicrobial efficacy of substituted arylidene-based quinazolin-4(3H)-one motifs
por: Oduselu, Gbolahan O., et al.
Publicado: (2023)

Anopheles gambiae Trehalase Inhibitors for Malaria Vector Control: A Molecular Docking and Molecular Dynamics Study
por: Adedeji, Eunice O., et al.
Publicado: (2022)

MRI findings of hypomyelination in adenylosuccinate lyase deficiency
por: Kayfan, Samar, et al.
Publicado: (2018)

Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase
por: Van Laer, Bart, et al.
Publicado: (2018)

Clinical and molecular characterization of patients with adenylosuccinate lyase deficiency
por: Mastrogiorgio, Gerarda, et al.
Publicado: (2021)

Prevalence of adenylosuccinate lyase deficiency based on aggregated exome data
por: Ferreira, Carlos R.
Publicado: (2017)

Structure-based pharmacophore modeling, virtual screening, and molecular dynamics simulation studies for identification of Plasmodium falciparum 5-aminolevulinate synthase inhibitors
por: Oduselu, Gbolahan O., et al.
Publicado: (2023)

Establishment of a Protein Frequency Library and Its Application in the Reliable Identification of Specific Protein Interaction Partners
por: Boulon, Séverine, et al.
Publicado: (2010)

Pharmacophore-Aided Virtual Screening and Molecular Dynamics Simulation Identifies TrkB Agonists for Treatment of CDKL5-Deficiency Disorders
por: Ademuwagun, Ibitayo Abigail, et al.
Publicado: (2023)

Diagnosis of adenylosuccinate lyase deficiency by metabolomic profiling in plasma reveals a phenotypic spectrum
por: Donti, Taraka R., et al.
Publicado: (2016)

Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer
por: Zurlo, Giada, et al.
Publicado: (2019)

Adenylosuccinate lyase deficiency affects neurobehavior via perturbations to tyramine signaling in Caenorhabditis elegans
por: Moro, Corinna A., et al.
Publicado: (2023)

(Z)-N′-Hydroxy-4-(trifluoromethyl)benzimidamide
por: Liu, Fei, et al.
Publicado: (2011)

Very mild isolated intellectual disability caused by adenylosuccinate lyase deficiency: a new phenotype()
por: Macchiaiolo, Marina, et al.
Publicado: (2020)

Broadening phenotype of adenylosuccinate lyase deficiency: A novel clinical pattern resembling neuronal ceroid lipofuscinosis
por: Mastrangelo, Mario, et al.
Publicado: (2019)

Novel mutations in ADSL for Adenylosuccinate Lyase Deficiency identified by the combination of Trio-WES and constantly updated guidelines
por: Mao, Xiao, et al.
Publicado: (2017)

Carcinogenic effect of adenylosuccinate lyase (ADSL) in prostate cancer development and progression through the cell cycle pathway
por: Liao, Jinling, et al.
Publicado: (2021)

A mild form of adenylosuccinate lyase deficiency in absence of typical brain MRI features diagnosed by whole exome sequencing
por: Macchiaiolo, Marina, et al.
Publicado: (2017)

Child with adenylosuccinate lyase deficiency caused by a novel complex heterozygous mutation in the ADSL gene: A case report
por: Wang, Xing-Chen, et al.
Publicado: (2022)

Investigating Immunization With Nucleotide Enzymes of Schistosoma mansoni: Nucleoside Diphosphate Kinase and Adenylosuccinate Lyase as New Antigenic Targets Against Schistosomiasis
por: Cagnazzo, Túlio di Orlando, et al.
Publicado: (2020)

Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis
por: Taha-Mehlitz, Stephanie, et al.
Publicado: (2021)

OR05-02 Silencing Of Adenylosuccinate Lyase Impairs Growth And Perturbs Mitochondrial Function Of Endocrine Therapy Resistant Breast Cancer Cells
por: Yadav, Anil K, et al.
Publicado: (2023)

Truncation, Randomization, and Selection: GENERATION OF A REDUCED LENGTH c-Jun ANTAGONIST THAT RETAINS HIGH INTERACTION STABILITY
por: Crooks, Richard O., et al.
Publicado: (2011)

A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by von willebrand factor
por: South, Kieron, et al.
Publicado: (2017)

Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery
por: Fyfe, Paul K., et al.
Publicado: (2010)

Structural Insights into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2
por: Newman, Joseph A, et al.
Publicado: (2015)

Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine
por: Ziółkowska, Natasza E., et al.
Publicado: (2007)

Characterization of Chromoshadow Domain-mediated Binding of Heterochromatin Protein 1α (HP1α) to Histone H3
por: Richart, Alexandria N., et al.
Publicado: (2012)

Specialized Hsp70 Chaperone (HscA) Binds Preferentially to the Disordered Form, whereas J-protein (HscB) Binds Preferentially to the Structured Form of the Iron-Sulfur Cluster Scaffold Protein (IscU)
por: Kim, Jin Hae, et al.
Publicado: (2012)

Human Mitochondrial Chaperone (mtHSP70) and Cysteine Desulfurase (NFS1) Bind Preferentially to the Disordered Conformation, Whereas Co-chaperone (HSC20) Binds to the Structured Conformation of the Iron-Sulfur Cluster Scaffold Protein (ISCU)
por: Cai, Kai, et al.
Publicado: (2013)

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): THREE-DIMENSIONAL STRUCTURE AND LOCALIZATION OF A CHANNEL GATE
por: Rosenberg, Mark F., et al.
Publicado: (2011)

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition
por: Dall, Elfriede, et al.
Publicado: (2020)

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini
por: Ouyang, Hui, et al.
Publicado: (2012)

A Novel Family of Apicomplexan Glideosome-associated Proteins with an Inner Membrane-anchoring Role
por: Bullen, Hayley E., et al.
Publicado: (2009)

The p53 Core Domain Is a Molten Globule at Low pH: FUNCTIONAL IMPLICATIONS OF A PARTIALLY UNFOLDED STRUCTURE
por: Ano Bom, Ana Paula D., et al.
Publicado: (2010)

Evidence for Steric Regulation of Fibrinogen Binding to Staphylococcus aureus Fibronectin-binding Protein A (FnBPA)
por: Stemberk, Vaclav, et al.
Publicado: (2014)

In silico Structure Prediction, Molecular Docking, and Dynamic Simulation of Plasmodium falciparum AP2-I Transcription Factor
por: Oladejo, David O, et al.
Publicado: (2023)

Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor
por: Ravn, Peter, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ti74adb6k5nrfroel23pm5fav6