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The Emergence of Avian Orthoavulavirus 13 in Wild Migratory Waterfowl in China Revealed the Existence of Diversified Trailer Region Sequences and HN Gene Lengths within this Serotype

Avian orthoavulavirus 13 (AOAV-13), also named avian paramyxovirus 13 (APMV-13), has been found sporadically in wild birds around the world ever since the discovery of AOAV-13 (AOAV-13/wild goose/Shimane/67/2000) in a wild goose from Japan in 2000. However, there are no reports of AOAV-13 in China....

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Autores principales: Fei, Yidong, Liu, Xinxin, Mu, Jiaqi, Li, Junjiao, Yu, Xibing, Chang, Jin, Bi, Yuhai, Stoeger, Tobias, Wajid, Abdul, Muzyka, Denys, Sharshov, Kirill, Shestopalov, Alexander, Amonsin, Alongkorn, Chen, Jianjun, Ding, Zhuang, Yin, Renfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669871/
https://www.ncbi.nlm.nih.gov/pubmed/31337066
http://dx.doi.org/10.3390/v11070646
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author Fei, Yidong
Liu, Xinxin
Mu, Jiaqi
Li, Junjiao
Yu, Xibing
Chang, Jin
Bi, Yuhai
Stoeger, Tobias
Wajid, Abdul
Muzyka, Denys
Sharshov, Kirill
Shestopalov, Alexander
Amonsin, Alongkorn
Chen, Jianjun
Ding, Zhuang
Yin, Renfu
author_facet Fei, Yidong
Liu, Xinxin
Mu, Jiaqi
Li, Junjiao
Yu, Xibing
Chang, Jin
Bi, Yuhai
Stoeger, Tobias
Wajid, Abdul
Muzyka, Denys
Sharshov, Kirill
Shestopalov, Alexander
Amonsin, Alongkorn
Chen, Jianjun
Ding, Zhuang
Yin, Renfu
author_sort Fei, Yidong
collection PubMed
description Avian orthoavulavirus 13 (AOAV-13), also named avian paramyxovirus 13 (APMV-13), has been found sporadically in wild birds around the world ever since the discovery of AOAV-13 (AOAV-13/wild goose/Shimane/67/2000) in a wild goose from Japan in 2000. However, there are no reports of AOAV-13 in China. In the present study, a novel AOAV-13 virus (AOAV-13/wild goose/China/Hubei/V93-1/2015), isolated from a wild migratory waterfowl in a wetland of Hubei province of China, during active surveillance from 2013 to 2018, was biologically and genetically characterized. Phylogenetic analyses demonstrated a very close genetic relationship among all AOAV-13 strains, as revealed by very few genetic variations. Moreover, pathogenicity tests indicated that the V93-1 strain is a low virulent virus for chickens. However, the genome of the V93-1 virus was found to be 16,158 nucleotides (nt) in length, which is 12 nt or 162 nt longer than the other AOAV-13 strains that have been reported to date. The length difference of 12 nt in strain V93-1 is due to the existence of three repeats of the conserved sequence, “AAAAAT”, in the 5′-end trailer of the genome. Moreover, the HN gene of the V93-1 virus is 2070 nt in size, encoding 610 aa, which is the same size as the AOAV-13 strain from Japan, whereas that of two strains from Ukraine and Kazakhstan are 2080 nt in length, encoding 579 aa. We describe a novel AOAV-13 in migratory waterfowl in China, which suggests that diversified trailer region sequences and HN gene lengths exist within serotype AOAV-13, and highlight the need for its constant surveillance in poultry from live animal markets, and especially migratory birds.
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spelling pubmed-66698712019-08-08 The Emergence of Avian Orthoavulavirus 13 in Wild Migratory Waterfowl in China Revealed the Existence of Diversified Trailer Region Sequences and HN Gene Lengths within this Serotype Fei, Yidong Liu, Xinxin Mu, Jiaqi Li, Junjiao Yu, Xibing Chang, Jin Bi, Yuhai Stoeger, Tobias Wajid, Abdul Muzyka, Denys Sharshov, Kirill Shestopalov, Alexander Amonsin, Alongkorn Chen, Jianjun Ding, Zhuang Yin, Renfu Viruses Brief Report Avian orthoavulavirus 13 (AOAV-13), also named avian paramyxovirus 13 (APMV-13), has been found sporadically in wild birds around the world ever since the discovery of AOAV-13 (AOAV-13/wild goose/Shimane/67/2000) in a wild goose from Japan in 2000. However, there are no reports of AOAV-13 in China. In the present study, a novel AOAV-13 virus (AOAV-13/wild goose/China/Hubei/V93-1/2015), isolated from a wild migratory waterfowl in a wetland of Hubei province of China, during active surveillance from 2013 to 2018, was biologically and genetically characterized. Phylogenetic analyses demonstrated a very close genetic relationship among all AOAV-13 strains, as revealed by very few genetic variations. Moreover, pathogenicity tests indicated that the V93-1 strain is a low virulent virus for chickens. However, the genome of the V93-1 virus was found to be 16,158 nucleotides (nt) in length, which is 12 nt or 162 nt longer than the other AOAV-13 strains that have been reported to date. The length difference of 12 nt in strain V93-1 is due to the existence of three repeats of the conserved sequence, “AAAAAT”, in the 5′-end trailer of the genome. Moreover, the HN gene of the V93-1 virus is 2070 nt in size, encoding 610 aa, which is the same size as the AOAV-13 strain from Japan, whereas that of two strains from Ukraine and Kazakhstan are 2080 nt in length, encoding 579 aa. We describe a novel AOAV-13 in migratory waterfowl in China, which suggests that diversified trailer region sequences and HN gene lengths exist within serotype AOAV-13, and highlight the need for its constant surveillance in poultry from live animal markets, and especially migratory birds. MDPI 2019-07-13 /pmc/articles/PMC6669871/ /pubmed/31337066 http://dx.doi.org/10.3390/v11070646 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Fei, Yidong
Liu, Xinxin
Mu, Jiaqi
Li, Junjiao
Yu, Xibing
Chang, Jin
Bi, Yuhai
Stoeger, Tobias
Wajid, Abdul
Muzyka, Denys
Sharshov, Kirill
Shestopalov, Alexander
Amonsin, Alongkorn
Chen, Jianjun
Ding, Zhuang
Yin, Renfu
The Emergence of Avian Orthoavulavirus 13 in Wild Migratory Waterfowl in China Revealed the Existence of Diversified Trailer Region Sequences and HN Gene Lengths within this Serotype
title The Emergence of Avian Orthoavulavirus 13 in Wild Migratory Waterfowl in China Revealed the Existence of Diversified Trailer Region Sequences and HN Gene Lengths within this Serotype
title_full The Emergence of Avian Orthoavulavirus 13 in Wild Migratory Waterfowl in China Revealed the Existence of Diversified Trailer Region Sequences and HN Gene Lengths within this Serotype
title_fullStr The Emergence of Avian Orthoavulavirus 13 in Wild Migratory Waterfowl in China Revealed the Existence of Diversified Trailer Region Sequences and HN Gene Lengths within this Serotype
title_full_unstemmed The Emergence of Avian Orthoavulavirus 13 in Wild Migratory Waterfowl in China Revealed the Existence of Diversified Trailer Region Sequences and HN Gene Lengths within this Serotype
title_short The Emergence of Avian Orthoavulavirus 13 in Wild Migratory Waterfowl in China Revealed the Existence of Diversified Trailer Region Sequences and HN Gene Lengths within this Serotype
title_sort emergence of avian orthoavulavirus 13 in wild migratory waterfowl in china revealed the existence of diversified trailer region sequences and hn gene lengths within this serotype
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669871/
https://www.ncbi.nlm.nih.gov/pubmed/31337066
http://dx.doi.org/10.3390/v11070646
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