The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases have emerged as critical regulators of immune responses. MARCH proteins target immune receptors, viral proteins as well as components in innate immune response for polyubiquitination and degradations via distinct ro...

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Detalles Bibliográficos
Autores principales: Lin, Heng, Li, Shu, Shu, Hong-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669941/
https://www.ncbi.nlm.nih.gov/pubmed/31404274
http://dx.doi.org/10.3389/fimmu.2019.01751
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author Lin, Heng
Li, Shu
Shu, Hong-Bing
author_facet Lin, Heng
Li, Shu
Shu, Hong-Bing
author_sort Lin, Heng
collection PubMed
description The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases have emerged as critical regulators of immune responses. MARCH proteins target immune receptors, viral proteins as well as components in innate immune response for polyubiquitination and degradations via distinct routes. This review summarizes the current progress about MARCH proteins and their regulation on immune responses.
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spelling pubmed-66699412019-08-09 The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation Lin, Heng Li, Shu Shu, Hong-Bing Front Immunol Immunology The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases have emerged as critical regulators of immune responses. MARCH proteins target immune receptors, viral proteins as well as components in innate immune response for polyubiquitination and degradations via distinct routes. This review summarizes the current progress about MARCH proteins and their regulation on immune responses. Frontiers Media S.A. 2019-07-24 /pmc/articles/PMC6669941/ /pubmed/31404274 http://dx.doi.org/10.3389/fimmu.2019.01751 Text en Copyright © 2019 Lin, Li and Shu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lin, Heng
Li, Shu
Shu, Hong-Bing
The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation
title The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation
title_full The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation
title_fullStr The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation
title_full_unstemmed The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation
title_short The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation
title_sort membrane-associated march e3 ligase family: emerging roles in immune regulation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669941/
https://www.ncbi.nlm.nih.gov/pubmed/31404274
http://dx.doi.org/10.3389/fimmu.2019.01751
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