Cargando…

Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival

BACKGROUND: Interleukin(IL)-30/IL-27p28 production by Prostate Cancer (PC) Stem-Like Cells (SLCs) has proven, in murine models, to be critical to tumor onset and progression. In PC patients, IL-30 expression by leukocytes infiltrating PC and draining lymph nodes correlates with advanced disease grad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sorrentino, Carlo, Yin, Zhinan, Ciummo, Stefania, Lanuti, Paola, Lu, Li-Fan, Marchisio, Marco, Bellone, Matteo, Di Carlo, Emma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670138/ https://www.ncbi.nlm.nih.gov/pubmed/31366386 http://dx.doi.org/10.1186/s40425-019-0668-z

Ejemplares similares

Interleukin-30 feeds breast cancer stem cells via CXCL10 and IL23 autocrine loops and shapes immune contexture and host outcome
por: Sorrentino, Carlo, et al.
Publicado: (2021)

Hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNγ signaling
por: Sorrentino, Carlo, et al.
Publicado: (2021)

Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival
por: D'Antonio, Luigi, et al.
Publicado: (2023)

Cell type specific IL-27p28 (IL-30) deletion in mice uncovers an unexpected regulatory function of IL-30 in autoimmune inflammation
por: Kim, Dongkyun, et al.
Publicado: (2023)

CRISPR/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and mortality
por: Sorrentino, Carlo, et al.
Publicado: (2022)

Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes
por: Petes, Carlene, et al.
Publicado: (2018)

IL-27, IL-30, and IL-35: A Cytokine Triumvirate in Cancer
por: Kourko, Olena, et al.
Publicado: (2019)

The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs
por: Ciummo, Stefania Livia, et al.
Publicado: (2021)

The antitumor potential of Interleukin-27 in prostate cancer
por: Di Carlo, Emma, et al.
Publicado: (2013)

IL-30(†) (IL-27A): a familiar stranger in immunity, inflammation, and cancer
por: Min, Booki, et al.
Publicado: (2021)

Associations of IL-27 Polymorphisms and Serum IL-27p28 Levels With Osteosarcoma Risk
por: Tang, Yu-jin, et al.
Publicado: (2014)

Colorectal Cancer-Associated Immune Exhaustion Involves T and B Lymphocytes and Conventional NK Cells and Correlates With a Shorter Overall Survival
por: Sorrentino, Carlo, et al.
Publicado: (2021)

Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control
por: Ruiz-Riol, M., et al.
Publicado: (2017)

Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease
por: Gong, Huanle, et al.
Publicado: (2022)

Interleukin-30: A novel microenvironmental hallmark of prostate cancer progression
por: Di Carlo, Emma
Publicado: (2014)

Decoding the Role of Interleukin-30 in the Crosstalk between Cancer and Myeloid Cells
por: Di Carlo, Emma
Publicado: (2020)

Much More Than IL-17A: Cytokines of the IL-17 Family Between Microbiota and Cancer
por: Brevi, Arianna, et al.
Publicado: (2020)

Plasma Interleukin-27 (IL-27) Levels Are Not Modulated in Patients with Chronic HIV-1 Infection
por: Swaminathan, Sanjay, et al.
Publicado: (2014)

Identification of the correlations between interleukin-27 (IL-27) and immune-inflammatory imbalance in preterm birth
por: Ran, Yuxin, et al.
Publicado: (2021)

IL-23/IL-27 Ratio in Peripheral Blood of Patients with Breast Cancer
por: Khodadadi, Ali, et al.
Publicado: (2014)

A role for IL-27p28 as an antagonist of gp130-mediated signaling
por: Stumhofer, Jason S., et al.
Publicado: (2010)

Host genetics of HCV disease — IL28B
por: Fellay, J
Publicado: (2010)

Dual Roles of IL-27 in Cancer Biology and Immunotherapy
por: Fabbi, Marina, et al.
Publicado: (2017)

Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma
por: Farahani, Rahim, et al.
Publicado: (2014)

Assessment of Interleukins IL-4, IL-6, IL-8, IL-10 in Acute Urticaria
por: Papadopoulos, Jordan, et al.
Publicado: (2014)

IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses
por: Suwanpradid, Jutamas, et al.
Publicado: (2021)

Identification of Pro-Inflammatory Cytokines Associated with Muscle Invasive Bladder Cancer; The Roles of IL-5, IL-20, and IL-28A
por: Lee, Se-Jung, et al.
Publicado: (2012)

Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27
por: Xu, Mingli, et al.
Publicado: (2010)

Non-Redundant Role for IL-12 and IL-27 in Modulating Th2 Polarization of Carcinoembryonic Antigen Specific CD4 T Cells from Pancreatic Cancer Patients
por: Tassi, Elena, et al.
Publicado: (2009)

Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis
por: Iwaszko, Milena, et al.
Publicado: (2021)

The role of cytokines in seizures: interleukin (IL)-1β, IL-1Ra, IL-8, and IL-10
por: Youn, Youngah, et al.
Publicado: (2013)

Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies
por: Tawara, Ken, et al.
Publicado: (2011)

Adhesion of Immature and Mature T Cells Induces in Human Thymic Epithelial Cells (TEC) Activation of IL-6 Gene Trascription Factors (NF-κB And NF-IL6) and IL-6 Gene Expression : Role of αtβ1 and α6β4 Integrins
por: Fiorini, Emma, et al.
Publicado: (2000)

Editorial: IL-27 in health and disease
por: Imamichi, Tomozumi, et al.
Publicado: (2023)

IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells
por: Choi, Yeon Ho, et al.
Publicado: (2019)

Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells
por: Yao, Yongxue, et al.
Publicado: (2005)

The Role of Interleukin-1 cytokine family (IL-1β, IL-37) and interleukin-12 cytokine family (IL-12, IL-35) in eumycetoma infection pathogenesis
por: Abushouk, Amir, et al.
Publicado: (2019)

Cabozantinib and IL-27 combinatorial therapy for bone-metastatic prostate cancer
por: Kumar, Shreya, et al.
Publicado: (2023)

IL-27 Regulates IL-18 Binding Protein in Skin Resident Cells
por: Wittmann, Miriam, et al.
Publicado: (2012)

IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10
por: Fonseca, Miriam M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_c65qahpvb6vhsdfc2oob2g5mia