Modified substrate specificity of a methyltransferase domain by protein insertion into an adenylation domain of the bassianolide synthetase

BACKGROUND: Creating designer molecules using a combination of select domains from polyketide synthases and/or nonribosomal peptide synthetases (NRPS) continues to be a synthetic goal. However, an incomplete understanding of how protein-protein interactions and dynamics affect each of the domain fun...

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Detalles Bibliográficos
Autores principales: Xu, Fuchao, Butler, Russell, May, Kyle, Rexhepaj, Megi, Yu, Dayu, Zi, Jiachen, Chen, Yi, Liang, Yonghong, Zeng, Jia, Hevel, Joan, Zhan, Jixun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670151/
https://www.ncbi.nlm.nih.gov/pubmed/31388353
http://dx.doi.org/10.1186/s13036-019-0195-y

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