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High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study
BACKGROUND: The results remain controversial with regards to the impact of serum uric acid on clinical outcomes from peritoneal dialysis population. The aim of our study was to investigate the influence of serum uric acid levels on mortality in peritoneal dialysis patients. METHODS: Data on 9405 per...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670192/ https://www.ncbi.nlm.nih.gov/pubmed/31388342 http://dx.doi.org/10.1186/s12986-019-0379-y |
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author | Xiang, Shilong Zhang, Xiaohui Xie, Xishao Wang, Junni Zhou, Qin Chen, Zhimin Wang, Yaomin Liu, Guangjun Han, Fei Chen, Jianghua |
author_facet | Xiang, Shilong Zhang, Xiaohui Xie, Xishao Wang, Junni Zhou, Qin Chen, Zhimin Wang, Yaomin Liu, Guangjun Han, Fei Chen, Jianghua |
author_sort | Xiang, Shilong |
collection | PubMed |
description | BACKGROUND: The results remain controversial with regards to the impact of serum uric acid on clinical outcomes from peritoneal dialysis population. The aim of our study was to investigate the influence of serum uric acid levels on mortality in peritoneal dialysis patients. METHODS: Data on 9405 peritoneal dialysis patients from the Zhejiang Renal Data system were retrospectively analyzed. All demographic and laboratory data were recorded at baseline. The study cohort was divided into quintiles according to baseline uric acid level (mg/dL): Q1 (< 6.06), Q2 (6.06–6.67), Q3 (6.68–7.27) (reference), Q4 (7.28–8.03), and Q5 (≥8.04). Hazards ratio (HR) of all-cause and cardiovascular mortality was calculated. RESULTS: Mean serum uric acid was 7.07 ± 1.25 mg/dL. During a median follow-up of 29.4 (range, 3.0 to 115.4) months, 1226 (13.0%) patients died, of which 515 (5.5%) died of cardiovascular events. The Kaplan-Meier survival curves showed that patients in the middle uric acid quintile (Q3: 6.68–7.27) exhibited the highest patient and cardiovascular survival rates (log-rank test P < 0.05). Multivariate Cox regression analysis showed that, using Q3 as the reference, in the fully adjusted model, a higher uric acid level (Q4: 7.28–8.03, and Q5: ≥8.04) was significantly associated with higher all-cause mortality (Model 3; Q4: HR, 1.335, 95% CI, 1.073 to 1.662, P = 0.009; Q5: HR, 1.482, 95% CI, 1.187 to 1.849, P = 0.001), but not with cardiovascular mortality. The adverse effect of higher uric acid level (≥7.28 mg/dL) on all-cause mortality was more prominent in groups such as male, hypoalbuminemia, normal weight, non-diabetes mellitus at baseline rather than in their counterparts respectively. CONCLUSIONS: A higher uric acid level was an independent risk factor for all-cause mortality in peritoneal dialysis patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12986-019-0379-y) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6670192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-66701922019-08-06 High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study Xiang, Shilong Zhang, Xiaohui Xie, Xishao Wang, Junni Zhou, Qin Chen, Zhimin Wang, Yaomin Liu, Guangjun Han, Fei Chen, Jianghua Nutr Metab (Lond) Research BACKGROUND: The results remain controversial with regards to the impact of serum uric acid on clinical outcomes from peritoneal dialysis population. The aim of our study was to investigate the influence of serum uric acid levels on mortality in peritoneal dialysis patients. METHODS: Data on 9405 peritoneal dialysis patients from the Zhejiang Renal Data system were retrospectively analyzed. All demographic and laboratory data were recorded at baseline. The study cohort was divided into quintiles according to baseline uric acid level (mg/dL): Q1 (< 6.06), Q2 (6.06–6.67), Q3 (6.68–7.27) (reference), Q4 (7.28–8.03), and Q5 (≥8.04). Hazards ratio (HR) of all-cause and cardiovascular mortality was calculated. RESULTS: Mean serum uric acid was 7.07 ± 1.25 mg/dL. During a median follow-up of 29.4 (range, 3.0 to 115.4) months, 1226 (13.0%) patients died, of which 515 (5.5%) died of cardiovascular events. The Kaplan-Meier survival curves showed that patients in the middle uric acid quintile (Q3: 6.68–7.27) exhibited the highest patient and cardiovascular survival rates (log-rank test P < 0.05). Multivariate Cox regression analysis showed that, using Q3 as the reference, in the fully adjusted model, a higher uric acid level (Q4: 7.28–8.03, and Q5: ≥8.04) was significantly associated with higher all-cause mortality (Model 3; Q4: HR, 1.335, 95% CI, 1.073 to 1.662, P = 0.009; Q5: HR, 1.482, 95% CI, 1.187 to 1.849, P = 0.001), but not with cardiovascular mortality. The adverse effect of higher uric acid level (≥7.28 mg/dL) on all-cause mortality was more prominent in groups such as male, hypoalbuminemia, normal weight, non-diabetes mellitus at baseline rather than in their counterparts respectively. CONCLUSIONS: A higher uric acid level was an independent risk factor for all-cause mortality in peritoneal dialysis patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12986-019-0379-y) contains supplementary material, which is available to authorized users. BioMed Central 2019-08-01 /pmc/articles/PMC6670192/ /pubmed/31388342 http://dx.doi.org/10.1186/s12986-019-0379-y Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Xiang, Shilong Zhang, Xiaohui Xie, Xishao Wang, Junni Zhou, Qin Chen, Zhimin Wang, Yaomin Liu, Guangjun Han, Fei Chen, Jianghua High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study |
title | High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study |
title_full | High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study |
title_fullStr | High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study |
title_full_unstemmed | High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study |
title_short | High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study |
title_sort | high serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670192/ https://www.ncbi.nlm.nih.gov/pubmed/31388342 http://dx.doi.org/10.1186/s12986-019-0379-y |
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