Cargando…

Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer

BACKGROUND: Metabolic reprogramming is a key feature of malignant cells. While glucose is one of the primary substrates for malignant cells, cancer cells also display a remarkable metabolic flexibility. Depending on nutrient availability and requirements, cancer cells will utilize alternative fuel s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Montal, Emily D., Bhalla, Kavita, Dewi, Ruby E., Ruiz, Christian F., Haley, John A., Ropell, Ashley E., Gordon, Chris, Haley, John D., Girnun, Geoffrey D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670241/ https://www.ncbi.nlm.nih.gov/pubmed/31388420 http://dx.doi.org/10.1186/s40170-019-0199-6

Ejemplares similares

Phosphoenolpyruvate carboxykinases as emerging targets in cancer therapy
por: Yu, Yong, et al.
Publicado: (2023)

Kinetic and functional properties of human mitochondrial phosphoenolpyruvate carboxykinase
por: Escós, Miriam, et al.
Publicado: (2016)

The requirement of phosphoenolpyruvate carboxykinase 1 for angiogenesis in vitro and in vivo
por: Yao, Jin, et al.
Publicado: (2022)

Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
por: Gonzalez-Rellan, María J., et al.
Publicado: (2023)

Integrating multiple regulations on enzyme activity: the case of phosphoenolpyruvate carboxykinases
por: Rojas, Bruno E, et al.
Publicado: (2023)

Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion
por: Stark, Romana, et al.
Publicado: (2009)

Effects of heterologous expression of phosphoenolpyruvate carboxykinase and phosphoenolpyruvate carboxylase on organic acid production in Aspergillus carbonarius
por: Yang, Lei, et al.
Publicado: (2015)

Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism
por: Hakimi, Parvin, et al.
Publicado: (2005)

Structural and Functional Studies of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis
por: Machová, Iva, et al.
Publicado: (2015)

Phosphoenolpyruvate Carboxykinase Maintains Glycolysis-driven Growth in Drosophila Tumors
por: Hussain, Rashid, et al.
Publicado: (2017)

Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis
por: Yu, Shuo, et al.
Publicado: (2021)

Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity
por: Latorre-Muro, Pedro, et al.
Publicado: (2021)

The Role of Cysteine Residues in Catalysis of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis
por: Machová, Iva, et al.
Publicado: (2017)

Melatonin stimulates transcription of the rat phosphoenolpyruvate carboxykinase gene in hepatic cells
por: Asano, Kosuke, et al.
Publicado: (2020)

Decoupling of Nrf2 Expression Promotes Mesenchymal State Maintenance in Non-Small Cell Lung Cancer
por: Haley, John A., et al.
Publicado: (2019)

Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells
por: Park, Ji-Won, et al.
Publicado: (2014)

Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors
por: Hidalgo, Jorge, et al.
Publicado: (2016)

Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5
por: Shen, Qingya, et al.
Publicado: (2018)

Identification of phosphoenolpyruvate carboxykinase 1 as a potential therapeutic target for pancreatic cancer
por: Zhu, Xiao-ren, et al.
Publicado: (2021)

Biallelic pathogenic variants in the mitochondrial form of phosphoenolpyruvate carboxykinase cause peripheral neuropathy
por: Sondheimer, Neal, et al.
Publicado: (2023)

Rapid Nitration of Adipocyte Phosphoenolpyruvate Carboxykinase by Leptin Reduces Glyceroneogenesis and Induces Fatty Acid Release
por: Jaubert, Anne-Marie, et al.
Publicado: (2012)

Enhancement of porcine intramuscular fat content by overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase in skeletal muscle
por: Ren, Zijian, et al.
Publicado: (2017)

Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males
por: Goncalves, Jimmy, et al.
Publicado: (2020)

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Osteogenic Differentiation by Modulating AMPK/ULK1‐Dependent Autophagy
por: Li, Zheng, et al.
Publicado: (2019)

A Novel Function of Mitochondrial Phosphoenolpyruvate Carboxykinase as a Regulator of Inflammatory Response in Kupffer Cells
por: Dong, Haibo, et al.
Publicado: (2021)

O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α
por: Latorre, Pedro, et al.
Publicado: (2017)

T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased β-cell proliferation
por: Katz, Liora S., et al.
Publicado: (2022)

Correction: O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α
Publicado: (2017)

Expanding the clinical spectrum of cytosolic phosphoenolpyruvate carboxykinase deficiency: novel PCK1 variants in four Arabian Gulf families
por: Al Busaidi, Marwa, et al.
Publicado: (2023)

The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells
por: Brearley, Madelaine C., et al.
Publicado: (2020)

Induction of Phosphoenolpyruvate Carboxykinase (PEPCK) during Acute Acidosis and Its Role in Acid Secretion by V-ATPase-Expressing Ionocytes
por: Furukawa, Fumiya, et al.
Publicado: (2015)

The impact of vitamin A supplementation on thyroid function and insulin sensitivity: implication of deiodinases and phosphoenolpyruvate carboxykinase in male Wistar rats
por: Saleh, Samar R., et al.
Publicado: (2022)

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth
por: Brown, D. M., et al.
Publicado: (2016)

Phosphoenolpyruvate Carboxykinase 1 Gene (Pck1) Displays Parallel Evolution between Old World and New World Fruit Bats
por: Zhu, Lei, et al.
Publicado: (2015)

Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
por: Bian, Xue-li, et al.
Publicado: (2017)

Overcoming chemoresistance to b-raf inhibitor in melanoma via targeted inhibition of phosphoenolpyruvate carboxykinase1 using 3-mercaptopropionic acid
por: Ren, Ming, et al.
Publicado: (2022)

Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor‐positive breast cancer via regulation of the mTOR pathway
por: Hsu, Hui‐Ping, et al.
Publicado: (2022)

MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5
por: Cheung, Alvin Ho-Kwan, et al.
Publicado: (2023)

Phosphoenolpyruvate Carboxykinase, a Key Enzyme That Controls Blood Glucose, Is a Target of Retinoic Acid Receptor-Related Orphan Receptor α
por: Matsuoka, Hiroshi, et al.
Publicado: (2015)

REGULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE AND TYROSINE TRANSAMINASE IN HEPATOMA CELL CULTURES : III. Comparative Studies in H35, HTC, MH(1)C(1), and RLC Cells
por: van Rijn, Han, et al.
Publicado: (1974)

Cannot write session to /tmp/vufind_sessions/sess_oskkeb7fmjnia9siamksb1fkuh