Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility

The biological basis of the increased risk for psychiatric disorders seen in 15q11.2 copy number deletion is unknown. Previous work has shown disturbances in white matter tracts in human carriers of the deletion. Here, in a novel rat model, we recapitulated low dosage of the candidate risk gene CYFI...

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Detalles Bibliográficos
Autores principales: Silva, Ana I., Haddon, Josephine E., Ahmed Syed, Yasir, Trent, Simon, Lin, Tzu-Ching E., Patel, Yateen, Carter, Jenny, Haan, Niels, Honey, Robert C., Humby, Trevor, Assaf, Yaniv, Owen, Michael J., Linden, David E. J., Hall, Jeremy, Wilkinson, Lawrence S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671959/
https://www.ncbi.nlm.nih.gov/pubmed/31371763
http://dx.doi.org/10.1038/s41467-019-11119-7

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