Cargando…
Chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons
Self-assembly of twelve pentatopic tectons, which have complementary edges or can be linked using either digonal or trigonal connectors, represents the optimal synthetic strategy to achieve spherical objects, such as chemical capsids. This process requires conditions that secure uninterrupted equili...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671967/ https://www.ncbi.nlm.nih.gov/pubmed/31371724 http://dx.doi.org/10.1038/s41467-019-11457-6 |
_version_ | 1783440559657975808 |
---|---|
author | Chen, Yu-Sheng Solel, Ephrath Huang, Yi-Fan Wang, Chien-Lung Tu, Tsung-Han Keinan, Ehud Chan, Yi-Tsu |
author_facet | Chen, Yu-Sheng Solel, Ephrath Huang, Yi-Fan Wang, Chien-Lung Tu, Tsung-Han Keinan, Ehud Chan, Yi-Tsu |
author_sort | Chen, Yu-Sheng |
collection | PubMed |
description | Self-assembly of twelve pentatopic tectons, which have complementary edges or can be linked using either digonal or trigonal connectors, represents the optimal synthetic strategy to achieve spherical objects, such as chemical capsids. This process requires conditions that secure uninterrupted equilibria of binding and self-correction en route to the global energy minimum. Here we report the synthesis of a highly soluble, deca-heterosubstituted corannulene that bears five terpyridine ligands. Spontaneous self-assembly of twelve such tectons with 30 cadmium(II) cations produces a giant icosahedral capsid as a thermodynamically stable single product in high yield. Nuclear magnetic resonance (NMR) methods, mass spectrometry analyses, small-angle X-ray scattering, transmission electron microscopy, and atomic force microscopy indicate that this spherical capsid has an external diameter of nearly 6 nm and shell thickness of 1 nm, in agreement with molecular modeling. NMR and liquid chromatography evidences imply that chiral self-sorting complexation generates a racemic mixture of homochiral capsids. |
format | Online Article Text |
id | pubmed-6671967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-66719672019-08-02 Chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons Chen, Yu-Sheng Solel, Ephrath Huang, Yi-Fan Wang, Chien-Lung Tu, Tsung-Han Keinan, Ehud Chan, Yi-Tsu Nat Commun Article Self-assembly of twelve pentatopic tectons, which have complementary edges or can be linked using either digonal or trigonal connectors, represents the optimal synthetic strategy to achieve spherical objects, such as chemical capsids. This process requires conditions that secure uninterrupted equilibria of binding and self-correction en route to the global energy minimum. Here we report the synthesis of a highly soluble, deca-heterosubstituted corannulene that bears five terpyridine ligands. Spontaneous self-assembly of twelve such tectons with 30 cadmium(II) cations produces a giant icosahedral capsid as a thermodynamically stable single product in high yield. Nuclear magnetic resonance (NMR) methods, mass spectrometry analyses, small-angle X-ray scattering, transmission electron microscopy, and atomic force microscopy indicate that this spherical capsid has an external diameter of nearly 6 nm and shell thickness of 1 nm, in agreement with molecular modeling. NMR and liquid chromatography evidences imply that chiral self-sorting complexation generates a racemic mixture of homochiral capsids. Nature Publishing Group UK 2019-08-01 /pmc/articles/PMC6671967/ /pubmed/31371724 http://dx.doi.org/10.1038/s41467-019-11457-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Chen, Yu-Sheng Solel, Ephrath Huang, Yi-Fan Wang, Chien-Lung Tu, Tsung-Han Keinan, Ehud Chan, Yi-Tsu Chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons |
title | Chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons |
title_full | Chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons |
title_fullStr | Chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons |
title_full_unstemmed | Chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons |
title_short | Chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons |
title_sort | chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671967/ https://www.ncbi.nlm.nih.gov/pubmed/31371724 http://dx.doi.org/10.1038/s41467-019-11457-6 |
work_keys_str_mv | AT chenyusheng chemicalmimicryofviralcapsidselfassemblyviacorannulenebasedpentatopictectons AT solelephrath chemicalmimicryofviralcapsidselfassemblyviacorannulenebasedpentatopictectons AT huangyifan chemicalmimicryofviralcapsidselfassemblyviacorannulenebasedpentatopictectons AT wangchienlung chemicalmimicryofviralcapsidselfassemblyviacorannulenebasedpentatopictectons AT tutsunghan chemicalmimicryofviralcapsidselfassemblyviacorannulenebasedpentatopictectons AT keinanehud chemicalmimicryofviralcapsidselfassemblyviacorannulenebasedpentatopictectons AT chanyitsu chemicalmimicryofviralcapsidselfassemblyviacorannulenebasedpentatopictectons |