Sexually dimorphic leanness and hypermobility in p16(Ink4a)/CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum

p16(Ink4a)/CDKN2A is a tumor suppressor that critically regulates the cell cycle. Indeed, p16(Ink4a) deficiency promotes tumor formation in various tissues. We now report that p16(Ink4a) deficiency in female mice, but not male mice, induces leanness especially in old age, as indicated by lower body...

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Detalles Bibliográficos
Autores principales: Kim, Kwang H., Cho, Yejin, Lee, Jaehoon, Jeong, Haengdueng, Lee, Yura, Kim, Soo In, Kim, Chang-Hoon, Lee, Han-Woong, Nam, Ki Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671985/
https://www.ncbi.nlm.nih.gov/pubmed/31371816
http://dx.doi.org/10.1038/s41598-019-47676-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671985/
https://www.ncbi.nlm.nih.gov/pubmed/31371816
http://dx.doi.org/10.1038/s41598-019-47676-6

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