Cargando…
Sexually dimorphic leanness and hypermobility in p16(Ink4a)/CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum
p16(Ink4a)/CDKN2A is a tumor suppressor that critically regulates the cell cycle. Indeed, p16(Ink4a) deficiency promotes tumor formation in various tissues. We now report that p16(Ink4a) deficiency in female mice, but not male mice, induces leanness especially in old age, as indicated by lower body...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671985/ https://www.ncbi.nlm.nih.gov/pubmed/31371816 http://dx.doi.org/10.1038/s41598-019-47676-6 |