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Production of seedable Amyloid-β peptides in model of prion diseases upon PrP(Sc)-induced PDK1 overactivation
The presence of amyloid beta (Aβ) plaques in the brain of some individuals with Creutzfeldt-Jakob or Gertsmann-Straussler-Scheinker diseases suggests that pathogenic prions (PrP(Sc)) would have stimulated the production and deposition of Aβ peptides. We here show in prion-infected neurons and mice t...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672003/ https://www.ncbi.nlm.nih.gov/pubmed/31371707 http://dx.doi.org/10.1038/s41467-019-11333-3 |