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The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system

Effective management of brain and spine tumors relies on a multidisciplinary approach encompassing surgery, radiation, and systemic therapy. In the era of personalized oncology, the latter is complemented by various molecularly targeting agents. Precise identification of cellular targets for these d...

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Autores principales: Wong, Derek, Shen, Yaoqing, Levine, Adrian B., Pleasance, Erin, Jones, Martin, Mungall, Karen, Thiessen, Brian, Toyota, Brian, Laskin, Janessa, Jones, Steven J.M., Marra, Marco A., Yip, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672021/
https://www.ncbi.nlm.nih.gov/pubmed/31371350
http://dx.doi.org/10.1101/mcs.a004143
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author Wong, Derek
Shen, Yaoqing
Levine, Adrian B.
Pleasance, Erin
Jones, Martin
Mungall, Karen
Thiessen, Brian
Toyota, Brian
Laskin, Janessa
Jones, Steven J.M.
Marra, Marco A.
Yip, Stephen
author_facet Wong, Derek
Shen, Yaoqing
Levine, Adrian B.
Pleasance, Erin
Jones, Martin
Mungall, Karen
Thiessen, Brian
Toyota, Brian
Laskin, Janessa
Jones, Steven J.M.
Marra, Marco A.
Yip, Stephen
author_sort Wong, Derek
collection PubMed
description Effective management of brain and spine tumors relies on a multidisciplinary approach encompassing surgery, radiation, and systemic therapy. In the era of personalized oncology, the latter is complemented by various molecularly targeting agents. Precise identification of cellular targets for these drugs requires comprehensive profiling of the cancer genome coupled with an efficient analytic pipeline, leading to an informed decision on drug selection, prognosis, and confirmation of the original pathological diagnosis. Acquisition of optimal tumor tissue for such analysis is paramount and often presents logistical challenges in neurosurgery. Here, we describe the experience and results of the Personalized OncoGenomics (POG) program with a focus on tumors of the central nervous system (CNS). Patients with recurrent CNS tumors were consented and enrolled into the POG program prior to accrual of tumor and matched blood followed by whole-genome and transcriptome sequencing and processing through the POG bioinformatic pipeline. Sixteen patients were enrolled into POG. In each case, POG analyses identified genomic drivers including novel oncogenic fusions, aberrant pathways, and putative therapeutic targets. POG has highlighted that personalized oncology is truly a multidisciplinary field, one in which neurosurgeons must play a vital role if these programs are to succeed and benefit our patients.
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spelling pubmed-66720212019-08-14 The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system Wong, Derek Shen, Yaoqing Levine, Adrian B. Pleasance, Erin Jones, Martin Mungall, Karen Thiessen, Brian Toyota, Brian Laskin, Janessa Jones, Steven J.M. Marra, Marco A. Yip, Stephen Cold Spring Harb Mol Case Stud Research Article Effective management of brain and spine tumors relies on a multidisciplinary approach encompassing surgery, radiation, and systemic therapy. In the era of personalized oncology, the latter is complemented by various molecularly targeting agents. Precise identification of cellular targets for these drugs requires comprehensive profiling of the cancer genome coupled with an efficient analytic pipeline, leading to an informed decision on drug selection, prognosis, and confirmation of the original pathological diagnosis. Acquisition of optimal tumor tissue for such analysis is paramount and often presents logistical challenges in neurosurgery. Here, we describe the experience and results of the Personalized OncoGenomics (POG) program with a focus on tumors of the central nervous system (CNS). Patients with recurrent CNS tumors were consented and enrolled into the POG program prior to accrual of tumor and matched blood followed by whole-genome and transcriptome sequencing and processing through the POG bioinformatic pipeline. Sixteen patients were enrolled into POG. In each case, POG analyses identified genomic drivers including novel oncogenic fusions, aberrant pathways, and putative therapeutic targets. POG has highlighted that personalized oncology is truly a multidisciplinary field, one in which neurosurgeons must play a vital role if these programs are to succeed and benefit our patients. Cold Spring Harbor Laboratory Press 2019-08 /pmc/articles/PMC6672021/ /pubmed/31371350 http://dx.doi.org/10.1101/mcs.a004143 Text en © 2019 Wong et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/) , which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited.
spellingShingle Research Article
Wong, Derek
Shen, Yaoqing
Levine, Adrian B.
Pleasance, Erin
Jones, Martin
Mungall, Karen
Thiessen, Brian
Toyota, Brian
Laskin, Janessa
Jones, Steven J.M.
Marra, Marco A.
Yip, Stephen
The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system
title The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system
title_full The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system
title_fullStr The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system
title_full_unstemmed The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system
title_short The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system
title_sort pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672021/
https://www.ncbi.nlm.nih.gov/pubmed/31371350
http://dx.doi.org/10.1101/mcs.a004143
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