Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation. Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of pro...

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Detalles Bibliográficos
Autores principales: Brennan, Christopher M., Vaites, Laura Pontano, Wells, Jonathan N., Santaguida, Stefano, Paulo, Joao A., Storchova, Zuzana, Harper, J. Wade, Marsh, Joseph A., Amon, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672052/
https://www.ncbi.nlm.nih.gov/pubmed/31196865
http://dx.doi.org/10.1101/gad.327494.119

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