Comparing human iPSC-cardiomyocytes versus HEK293T cells unveils disease-causing effects of Brugada mutation A735V of Na(V)1.5 sodium channels

Loss-of-function mutations of the SCN5A gene encoding for the sodium channel α-subunit Na(V)1.5 result in the autosomal dominant hereditary disease Brugada Syndrome (BrS) with a high risk of sudden cardiac death in the adult. We here engineered human induced pluripotent stem cell-derived cardiomyocy...

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Detalles Bibliográficos
Autores principales: de la Roche, Jeanne, Angsutararux, Paweorn, Kempf, Henning, Janan, Montira, Bolesani, Emiliano, Thiemann, Stefan, Wojciechowski, Daniel, Coffee, Michelle, Franke, Annika, Schwanke, Kristin, Leffler, Andreas, Luanpitpong, Sudjit, Issaragrisil, Surapol, Fischer, Martin, Zweigerdt, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673693/
https://www.ncbi.nlm.nih.gov/pubmed/31371804
http://dx.doi.org/10.1038/s41598-019-47632-4

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