High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

We investigated the role of 3D genome architecture in instructing functional properties of glioblastoma stem cells (GSCs) by generating sub-5-kb resolution 3D genome maps by in situ Hi-C. Contact maps at sub-5-kb resolution allow identification of individual DNA loops, domain organization, and large...

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Detalles Bibliográficos
Autores principales: Johnston, Michael J., Nikolic, Ana, Ninkovic, Nicoletta, Guilhamon, Paul, Cavalli, Florence M.G., Seaman, Steven, Zemp, Franz J., Lee, John, Abdelkareem, Aly, Ellestad, Katrina, Murison, Alex, Kushida, Michelle M., Coutinho, Fiona J., Ma, Yussanne, Mungall, Andrew J., Moore, Richard, Marra, Marco A., Taylor, Michael D., Dirks, Peter B., Pugh, Trevor J., Morrissy, Sorana, St Croix, Bradley, Mahoney, Douglas J., Lupien, Mathieu, Gallo, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673710/
https://www.ncbi.nlm.nih.gov/pubmed/31249064
http://dx.doi.org/10.1101/gr.246520.118

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