Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism

Simvastatin reduces pulmonary arterial pressure and right ventricular hypertrophy in animal models of pulmonary arterial hypertension (PAH) and is thought to restore endothelial dysfunction. In vivo effects of drugs are complicated by several factors and little is known of the direct effects of stat...

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Detalles Bibliográficos
Autores principales: Absi, Mais, Eid, Basma G., Ashton, Nick, Hart, George, Gurney, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675113/
https://www.ncbi.nlm.nih.gov/pubmed/31369604
http://dx.doi.org/10.1371/journal.pone.0220473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675113/
https://www.ncbi.nlm.nih.gov/pubmed/31369604
http://dx.doi.org/10.1371/journal.pone.0220473

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