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Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment
Lipoprotein-associated phospholipase A2 (Lp-PLA2) and superoxide dismutase (SOD) are linked to regulating vascular/neuro-inflammation and stroke. Using a retrospective design, we investigated whether circulating Lp-PLA2 and SOD in cerebral small vessel disease (CSVD) patients were associated with co...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675532/ https://www.ncbi.nlm.nih.gov/pubmed/31440388 http://dx.doi.org/10.14336/AD.2019.0304 |
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author | Zhu, Shuzhen Wei, Xiaobo Yang, Xiaohua Huang, Zifeng Chang, Zihan Xie, Fen Yang, Qin Ding, Changhai Xiang, Wei Yang, Hongjun Xia, Ying Feng, Zhong-Ping Sun, Hong-Shuo Yenari, Midori A Shi, Lin Mok, Vincent CT Wang, Qing |
author_facet | Zhu, Shuzhen Wei, Xiaobo Yang, Xiaohua Huang, Zifeng Chang, Zihan Xie, Fen Yang, Qin Ding, Changhai Xiang, Wei Yang, Hongjun Xia, Ying Feng, Zhong-Ping Sun, Hong-Shuo Yenari, Midori A Shi, Lin Mok, Vincent CT Wang, Qing |
author_sort | Zhu, Shuzhen |
collection | PubMed |
description | Lipoprotein-associated phospholipase A2 (Lp-PLA2) and superoxide dismutase (SOD) are linked to regulating vascular/neuro-inflammation and stroke. Using a retrospective design, we investigated whether circulating Lp-PLA2 and SOD in cerebral small vessel disease (CSVD) patients were associated with cognitive impairment. Eighty-seven CSVD patients were recruited. Plasma Lp-PLA2 and SOD were determined, and cognitive status was measured by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). The severity of white matter hypoerintensities (WMHs) in CSVD patients was rated according to Fazekas scales, and Lp-PLA2/SOD levels and MMSE/MoCA were compared. Multiple linear regressions were used to evaluate the relationship between Lp-PLA2 and SOD and the cognitive impairment. Ordinal logistic regression and generalized linear models (OLRGLMs) were applied to confirm whether Lp-PLA2 and SOD are independent risk factors for cognitive impairment in CVSD. Lp-PLA2 and SOD with mild or severe cognitive impairment were lower than those with normal congnition. Lp-PLA2 and SOD in CSVD patients with severe WMHs were significantly lower than those with mild or moderate WMH lesions. We noted positive linear associations of Lp-PLA and SOD with cognitive impairment in CSVD, independent of LDL-C. OLRGLMs confirmed that Lp-PLA2 and SOD were independent risk factors of cognitive impairment in CSVD. Lp-PLA2 and SOD are independently associated with cognitive impairment and WMH lesion, and may be useful for the rapid evaluation of cognitive impairment in CSVD. Lp-PLA2/SOD are modifiable factors that may be considered as therapeutic targets for preventing cognitive impairment in CSVD. |
format | Online Article Text |
id | pubmed-6675532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-66755322019-08-22 Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment Zhu, Shuzhen Wei, Xiaobo Yang, Xiaohua Huang, Zifeng Chang, Zihan Xie, Fen Yang, Qin Ding, Changhai Xiang, Wei Yang, Hongjun Xia, Ying Feng, Zhong-Ping Sun, Hong-Shuo Yenari, Midori A Shi, Lin Mok, Vincent CT Wang, Qing Aging Dis Orginal Article Lipoprotein-associated phospholipase A2 (Lp-PLA2) and superoxide dismutase (SOD) are linked to regulating vascular/neuro-inflammation and stroke. Using a retrospective design, we investigated whether circulating Lp-PLA2 and SOD in cerebral small vessel disease (CSVD) patients were associated with cognitive impairment. Eighty-seven CSVD patients were recruited. Plasma Lp-PLA2 and SOD were determined, and cognitive status was measured by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). The severity of white matter hypoerintensities (WMHs) in CSVD patients was rated according to Fazekas scales, and Lp-PLA2/SOD levels and MMSE/MoCA were compared. Multiple linear regressions were used to evaluate the relationship between Lp-PLA2 and SOD and the cognitive impairment. Ordinal logistic regression and generalized linear models (OLRGLMs) were applied to confirm whether Lp-PLA2 and SOD are independent risk factors for cognitive impairment in CVSD. Lp-PLA2 and SOD with mild or severe cognitive impairment were lower than those with normal congnition. Lp-PLA2 and SOD in CSVD patients with severe WMHs were significantly lower than those with mild or moderate WMH lesions. We noted positive linear associations of Lp-PLA and SOD with cognitive impairment in CSVD, independent of LDL-C. OLRGLMs confirmed that Lp-PLA2 and SOD were independent risk factors of cognitive impairment in CSVD. Lp-PLA2 and SOD are independently associated with cognitive impairment and WMH lesion, and may be useful for the rapid evaluation of cognitive impairment in CSVD. Lp-PLA2/SOD are modifiable factors that may be considered as therapeutic targets for preventing cognitive impairment in CSVD. JKL International LLC 2019-08-01 /pmc/articles/PMC6675532/ /pubmed/31440388 http://dx.doi.org/10.14336/AD.2019.0304 Text en Copyright: © 2019 Zhu et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Orginal Article Zhu, Shuzhen Wei, Xiaobo Yang, Xiaohua Huang, Zifeng Chang, Zihan Xie, Fen Yang, Qin Ding, Changhai Xiang, Wei Yang, Hongjun Xia, Ying Feng, Zhong-Ping Sun, Hong-Shuo Yenari, Midori A Shi, Lin Mok, Vincent CT Wang, Qing Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment |
title | Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment |
title_full | Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment |
title_fullStr | Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment |
title_full_unstemmed | Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment |
title_short | Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment |
title_sort | plasma lipoprotein-associated phospholipase a2 and superoxide dismutase are independent predicators of cognitive impairment in cerebral small vessel disease patients: diagnosis and assessment |
topic | Orginal Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675532/ https://www.ncbi.nlm.nih.gov/pubmed/31440388 http://dx.doi.org/10.14336/AD.2019.0304 |
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