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Deficiency of tPA Exacerbates White Matter Damage, Neuroinflammation, Glymphatic Dysfunction and Cognitive Dysfunction in Aging Mice
Tissue plasminogen activator (tPA) is a serine protease primarily involved in mediating thrombus breakdown and regulating catabolism of amyloid-beta (Aβ). The aim of this study is to investigate age-dependent decline of endogenous tPA and the effects of tPA decline on glymphatic function and cogniti...
Autores principales: | Yu, Peng, Venkat, Poornima, Chopp, Michael, Zacharek, Alex, Shen, Yi, Liang, Linlin, Landschoot-Ward, Julie, Liu, Zhongwu, Jiang, Rongcai, Chen, Jieli |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675536/ https://www.ncbi.nlm.nih.gov/pubmed/31440383 http://dx.doi.org/10.14336/AD.2018.0816 |
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