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Deficiency of tPA Exacerbates White Matter Damage, Neuroinflammation, Glymphatic Dysfunction and Cognitive Dysfunction in Aging Mice

Tissue plasminogen activator (tPA) is a serine protease primarily involved in mediating thrombus breakdown and regulating catabolism of amyloid-beta (Aβ). The aim of this study is to investigate age-dependent decline of endogenous tPA and the effects of tPA decline on glymphatic function and cogniti...

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Detalles Bibliográficos
Autores principales:	Yu, Peng, Venkat, Poornima, Chopp, Michael, Zacharek, Alex, Shen, Yi, Liang, Linlin, Landschoot-Ward, Julie, Liu, Zhongwu, Jiang, Rongcai, Chen, Jieli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	JKL International LLC 2019
Materias:	Orginal Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675536/ https://www.ncbi.nlm.nih.gov/pubmed/31440383 http://dx.doi.org/10.14336/AD.2018.0816

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