Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional Programs

The study of the origin and development of cerebellar tumors has been hampered by the complexity and heterogeneity of cerebellar cells that change over the course of development. We used single-cell transcriptomics to study >60,000 cells from the developing murine cerebellum, and show that differ...

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Detalles Bibliográficos
Autores principales: Vladoiu, Maria C, El-Hamamy, Ibrahim, Donovan, Laura K, Farooq, Hamza, Holgado, Borja L, Sundaravadanam, Yogi, Ramaswamy, Vijay, Hendrikse, Liam D., Kumar, Sachin, Mack, Stephen C, Lee, John JY, Fong, Vernon, Juraschka, Kyle, Przelicki, David, Michealraj, Antony, Skowron, Patryk, Luu, Betty, Suzuki, Hiromichi, Morrissy, A Sorana, Cavalli, Florence MG, Garzia, Livia, Daniels, Craig, Wu, Xiaochong, Qazi, Maleeha A, Singh, Sheila K, Chan, Jennifer A, Marra, Marco A, Malkin, David, Dirks, Peter, Heisler, Lawrence, Pugh, Trevor, Ng, Karen, Notta, Faiyaz, Thompson, Eric M., Kleinman, Claudia L, Joyner, Alexandra L., Jabado, Nada, Stein, Lincoln, Taylor, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675628/
https://www.ncbi.nlm.nih.gov/pubmed/31043743
http://dx.doi.org/10.1038/s41586-019-1158-7

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