CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation

Factors that underlie the clustering of metabolic syndrome traits are not fully known. We performed whole exome sequence analysis in kindreds with extreme phenotypes of early-onset atherosclerosis and metabolic syndrome and identified novel loss-of-function mutations in the gene encoding the pancrea...

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Detalles Bibliográficos
Autores principales: Esteghamat, Fatemehsadat, Broughton, James S., Smith, Emily, Cardone, Rebecca, Tyagi, Tarun, Guerra, Mateus, Szabó, András, Ugwu, Nelson, Mani, Mitra V., Azari, Bani, Kayingo, Gerald, Chung, Sunny, Fathzadeh, Mohsen, Weiss, Ephraim, Bender, Jeffrey, Mane, Shrikant, Lifton, Richard P., Adeniran, Adebowale, Nathanson, Michael H., Gorelick, Fred S., Hwa, John, Sahin-Tóth, Miklós, Belfort-DeAguiar, Renata, Kibbey, Richard G., Mani, Arya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675645/
https://www.ncbi.nlm.nih.gov/pubmed/31358993
http://dx.doi.org/10.1038/s41588-019-0470-3

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