NF1 mutations identify molecular and clinical subtypes of lung adenocarcinomas

The tumor suppressor gene neurofibromin 1 (NF1) is a major regulator of the RAS‐MAPK pathway. NF1 mutations occur in lung cancer but were not extensively explored. We hypothesized that NF1‐mutated tumors could define a specific population with a distinct clinical and molecular profile. We performed...

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Detalles Bibliográficos
Autores principales: Tlemsani, Camille, Pécuchet, Nicolas, Gruber, Aurelia, Laurendeau, Ingrid, Danel, Claire, Riquet, Marc, Le Pimpec‐Barthes, Françoise, Fabre, Elizabeth, Mansuet‐Lupo, Audrey, Damotte, Diane, Alifano, Marco, Luscan, Armelle, Rousseau, Benoit, Vidaud, Dominique, Varin, Jennifer, Parfait, Beatrice, Bieche, Ivan, Leroy, Karen, Laurent‐Puig, Pierre, Terris, Benoit, Blons, Helene, Vidaud, Michel, Pasmant, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675708/
https://www.ncbi.nlm.nih.gov/pubmed/31199580
http://dx.doi.org/10.1002/cam4.2175

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