Second primary malignancies in postpolycythemia vera and postessential thrombocythemia myelofibrosis: A study on 2233 patients

Patients with myeloproliferative neoplasms (MPN) are known to have higher incidence of nonhematological second primary malignancies (SPM) compared to general population. In the MYSEC study on 781 secondary myelofibrosis (SMF) patients, the incidence of SPM after SMF diagnosis resulted 0.98/100 patie...

Descripción completa

Detalles Bibliográficos
Autores principales: Mora, Barbara, Rumi, Elisa, Guglielmelli, Paola, Barraco, Daniela, Maffioli, Margherita, Rambaldi, Alessandro, Caramella, Marianna, Komrokji, Rami, Gotlib, Jason, Kiladjian, Jean Jacques, Cervantes, Francisco, Devos, Timothy, Palandri, Francesca, De Stefano, Valerio, Ruggeri, Marco, Silver, Richard T., Benevolo, Giulia, Albano, Francesco, Cavalloni, Chiara, Pietra, Daniela, Barbui, Tiziano, Rotunno, Giada, Cazzola, Mario, Vannucchi, Alessandro Maria, Giorgino, Toni, Passamonti, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675726/
https://www.ncbi.nlm.nih.gov/pubmed/31173472
http://dx.doi.org/10.1002/cam4.2107
Descripción
Sumario:Patients with myeloproliferative neoplasms (MPN) are known to have higher incidence of nonhematological second primary malignancies (SPM) compared to general population. In the MYSEC study on 781 secondary myelofibrosis (SMF) patients, the incidence of SPM after SMF diagnosis resulted 0.98/100 patient‐years. When including non‐melanoma skin cancers (NMSC), the incidence arose to 1.56/100 patient‐years. In SMF, JAK inhibitor treatment was associated only with NMSC occurrence. Then, we merged the MYSEC cohort with a large dataset of PV and ET not evolving into SMF. In this subanalysis, we did not find any correlation between SPM and SMF occurrence. These findings highlight the need of studies aimed at identifying MPN patients at higher risk of SPM.

Ejemplares similares