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Tic disorders revisited: introduction of the term “tic spectrum disorders”

Although the DSM-5 chronic motor tic disorder (CMTD) and Tourette syndrome (TS) are distinct diagnostic categories, there is no genetic or phenotypic evidence that supports this diagnostic categorization. The aim of this study was to compare patients with both diagnoses along a number of clinical ch...

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Autores principales: Müller-Vahl, Kirsten R., Sambrani, Tanvi, Jakubovski, Ewgeni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675752/
https://www.ncbi.nlm.nih.gov/pubmed/30661132
http://dx.doi.org/10.1007/s00787-018-01272-7
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author Müller-Vahl, Kirsten R.
Sambrani, Tanvi
Jakubovski, Ewgeni
author_facet Müller-Vahl, Kirsten R.
Sambrani, Tanvi
Jakubovski, Ewgeni
author_sort Müller-Vahl, Kirsten R.
collection PubMed
description Although the DSM-5 chronic motor tic disorder (CMTD) and Tourette syndrome (TS) are distinct diagnostic categories, there is no genetic or phenotypic evidence that supports this diagnostic categorization. The aim of this study was to compare patients with both diagnoses along a number of clinical characteristics to provide further diagnostic clarity. Our sample consisted of 1018 patients (including adult and child patients) suffering from chronic tic disorders. Tic severity was assessed via Shapiro Tourette-Syndrome Severity Scale (STSS). Lifetime prevalence of other comorbid conditions was assessed in a semi-structured clinical interview. The data were gained through retrospective chart analysis. The two groups did not differ significantly in any of the clinical or demographic variables. Patients only differed in tic severity, with CMTD patients (n = 40) having lower mean tic severity (STSS = 2.0 vs. 2.8; p < 0.001), prevalence of complex motor tics (27.5% vs. 55.9%; p < 0.01), copropraxia (0% vs. 16.2%; p < 0.01) and echopraxia (10.0% vs. 23.8%; p < 0.05), and a markedly lower comorbidity score (1.9 vs. 2.7; p < 0.001) as compared to TS patients (n = 978). Our results suggest that both disorders exist along a symptom severity continuum of which TS constitutes a more severe and CMTD a less severe form. We therefore suggest the introduction of the term “tic spectrum disorders”, instead of using different diagnostic categories. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00787-018-01272-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-66757522019-08-14 Tic disorders revisited: introduction of the term “tic spectrum disorders” Müller-Vahl, Kirsten R. Sambrani, Tanvi Jakubovski, Ewgeni Eur Child Adolesc Psychiatry Original Contribution Although the DSM-5 chronic motor tic disorder (CMTD) and Tourette syndrome (TS) are distinct diagnostic categories, there is no genetic or phenotypic evidence that supports this diagnostic categorization. The aim of this study was to compare patients with both diagnoses along a number of clinical characteristics to provide further diagnostic clarity. Our sample consisted of 1018 patients (including adult and child patients) suffering from chronic tic disorders. Tic severity was assessed via Shapiro Tourette-Syndrome Severity Scale (STSS). Lifetime prevalence of other comorbid conditions was assessed in a semi-structured clinical interview. The data were gained through retrospective chart analysis. The two groups did not differ significantly in any of the clinical or demographic variables. Patients only differed in tic severity, with CMTD patients (n = 40) having lower mean tic severity (STSS = 2.0 vs. 2.8; p < 0.001), prevalence of complex motor tics (27.5% vs. 55.9%; p < 0.01), copropraxia (0% vs. 16.2%; p < 0.01) and echopraxia (10.0% vs. 23.8%; p < 0.05), and a markedly lower comorbidity score (1.9 vs. 2.7; p < 0.001) as compared to TS patients (n = 978). Our results suggest that both disorders exist along a symptom severity continuum of which TS constitutes a more severe and CMTD a less severe form. We therefore suggest the introduction of the term “tic spectrum disorders”, instead of using different diagnostic categories. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00787-018-01272-7) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2019-01-19 2019 /pmc/articles/PMC6675752/ /pubmed/30661132 http://dx.doi.org/10.1007/s00787-018-01272-7 Text en © The Author(s) 2019 OpenAccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Contribution
Müller-Vahl, Kirsten R.
Sambrani, Tanvi
Jakubovski, Ewgeni
Tic disorders revisited: introduction of the term “tic spectrum disorders”
title Tic disorders revisited: introduction of the term “tic spectrum disorders”
title_full Tic disorders revisited: introduction of the term “tic spectrum disorders”
title_fullStr Tic disorders revisited: introduction of the term “tic spectrum disorders”
title_full_unstemmed Tic disorders revisited: introduction of the term “tic spectrum disorders”
title_short Tic disorders revisited: introduction of the term “tic spectrum disorders”
title_sort tic disorders revisited: introduction of the term “tic spectrum disorders”
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675752/
https://www.ncbi.nlm.nih.gov/pubmed/30661132
http://dx.doi.org/10.1007/s00787-018-01272-7
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