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Assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedation

BACKGROUND: Phase-lag entropy (PLE) was recently described as a measurement of temporal pattern diversity in the phase relationship between two electroencephalographic signals from prefrontal and frontal montages. This study was performed to evaluate the performance of PLE for assessing the depth of...

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Autores principales: Jun, Mi Roung, Yoo, Jae Hwa, Park, Sun Young, Na, Sojin, Kwon, Hyerim, Nho, Jae-Hwi, Kim, Soon Im
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Anesthesiologists 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676028/
https://www.ncbi.nlm.nih.gov/pubmed/31366188
http://dx.doi.org/10.4097/kja.d.19.00019
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author Jun, Mi Roung
Yoo, Jae Hwa
Park, Sun Young
Na, Sojin
Kwon, Hyerim
Nho, Jae-Hwi
Kim, Soon Im
author_facet Jun, Mi Roung
Yoo, Jae Hwa
Park, Sun Young
Na, Sojin
Kwon, Hyerim
Nho, Jae-Hwi
Kim, Soon Im
author_sort Jun, Mi Roung
collection PubMed
description BACKGROUND: Phase-lag entropy (PLE) was recently described as a measurement of temporal pattern diversity in the phase relationship between two electroencephalographic signals from prefrontal and frontal montages. This study was performed to evaluate the performance of PLE for assessing the depth of sedation. METHODS: Thirty adult patients undergoing upper limb surgery with a brachial plexus block were administered propofol by target-controlled infusion. The depth of sedation was assessed using the Observer’s Assessment of Alertness/Sedation (OAA/S) scale. The effect-site concentration (Ce) of propofol was initially started at 0.5 μg/ml and was increased in increments of 0.2 μg/ml until an OAA/S score of 1 was reached. Three minutes after the target Ce was reached, the PLE, bispectral index (BIS), and level of sedation were assessed. Correlations between the OAA/S score and PLE or BIS were determined. The prediction probabilities (P(k)) of PLE and BIS were also analyzed. RESULTS: The PLE values were closely correlated with the OAA/S scores (Spearman’s Rho = 0.755; P < 0.001) to an extent comparable with the correlation between the BIS and OAA/S score (Spearman’s Rho = 0.788; P < 0.001). The P(k) values of PLE and BIS were 0.731 and 0.718, respectively. CONCLUSIONS: PLE is a new and reliable consciousness monitoring system for assessing the depth of sedation induced by propofol, which is comparable with the BIS.
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spelling pubmed-66760282019-08-05 Assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedation Jun, Mi Roung Yoo, Jae Hwa Park, Sun Young Na, Sojin Kwon, Hyerim Nho, Jae-Hwi Kim, Soon Im Korean J Anesthesiol Clinical Research Article BACKGROUND: Phase-lag entropy (PLE) was recently described as a measurement of temporal pattern diversity in the phase relationship between two electroencephalographic signals from prefrontal and frontal montages. This study was performed to evaluate the performance of PLE for assessing the depth of sedation. METHODS: Thirty adult patients undergoing upper limb surgery with a brachial plexus block were administered propofol by target-controlled infusion. The depth of sedation was assessed using the Observer’s Assessment of Alertness/Sedation (OAA/S) scale. The effect-site concentration (Ce) of propofol was initially started at 0.5 μg/ml and was increased in increments of 0.2 μg/ml until an OAA/S score of 1 was reached. Three minutes after the target Ce was reached, the PLE, bispectral index (BIS), and level of sedation were assessed. Correlations between the OAA/S score and PLE or BIS were determined. The prediction probabilities (P(k)) of PLE and BIS were also analyzed. RESULTS: The PLE values were closely correlated with the OAA/S scores (Spearman’s Rho = 0.755; P < 0.001) to an extent comparable with the correlation between the BIS and OAA/S score (Spearman’s Rho = 0.788; P < 0.001). The P(k) values of PLE and BIS were 0.731 and 0.718, respectively. CONCLUSIONS: PLE is a new and reliable consciousness monitoring system for assessing the depth of sedation induced by propofol, which is comparable with the BIS. Korean Society of Anesthesiologists 2019-08 2019-07-30 /pmc/articles/PMC6676028/ /pubmed/31366188 http://dx.doi.org/10.4097/kja.d.19.00019 Text en Copyright © The Korean Society of Anesthesiologists, 2019 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Article
Jun, Mi Roung
Yoo, Jae Hwa
Park, Sun Young
Na, Sojin
Kwon, Hyerim
Nho, Jae-Hwi
Kim, Soon Im
Assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedation
title Assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedation
title_full Assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedation
title_fullStr Assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedation
title_full_unstemmed Assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedation
title_short Assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedation
title_sort assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedation
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676028/
https://www.ncbi.nlm.nih.gov/pubmed/31366188
http://dx.doi.org/10.4097/kja.d.19.00019
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