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Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease

Eosinophilic esophagitis (EoE) is a recently recognized esophageal inflammatory disease with clinical manifestations arising from esophageal dysfunction. The etiology of EoE is currently being clarified and food allergy is evolving as the central cornerstone of EoE disease pathogenesis. Given the la...

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Autores principales: Lianto, Priscilia, Zhang, Yani, Che, Huilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676061/
https://www.ncbi.nlm.nih.gov/pubmed/31384583
http://dx.doi.org/10.5415/apallergy.2019.9.e28
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author Lianto, Priscilia
Zhang, Yani
Che, Huilian
author_facet Lianto, Priscilia
Zhang, Yani
Che, Huilian
author_sort Lianto, Priscilia
collection PubMed
description Eosinophilic esophagitis (EoE) is a recently recognized esophageal inflammatory disease with clinical manifestations arising from esophageal dysfunction. The etiology of EoE is currently being clarified and food allergy is evolving as the central cornerstone of EoE disease pathogenesis. Given the large number of eosinophils in the esophagus of people with EoE verified by data from murine models EoE is widely considered as the hallmark T-helper type 2 (Th2) disease of the esophagus. It is also known that some eosinophilic inflammation is controlled by other subsets of T cells such as Th9 or Th17 and control is also exerted by type 2 innate lymphoid cells acting together with basophils. In this paper we review results from molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and present in-depth molecular understanding of EoE.
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spelling pubmed-66760612019-08-05 Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease Lianto, Priscilia Zhang, Yani Che, Huilian Asia Pac Allergy Current Review Eosinophilic esophagitis (EoE) is a recently recognized esophageal inflammatory disease with clinical manifestations arising from esophageal dysfunction. The etiology of EoE is currently being clarified and food allergy is evolving as the central cornerstone of EoE disease pathogenesis. Given the large number of eosinophils in the esophagus of people with EoE verified by data from murine models EoE is widely considered as the hallmark T-helper type 2 (Th2) disease of the esophagus. It is also known that some eosinophilic inflammation is controlled by other subsets of T cells such as Th9 or Th17 and control is also exerted by type 2 innate lymphoid cells acting together with basophils. In this paper we review results from molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and present in-depth molecular understanding of EoE. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2019-07-31 /pmc/articles/PMC6676061/ /pubmed/31384583 http://dx.doi.org/10.5415/apallergy.2019.9.e28 Text en Copyright © 2019. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Current Review
Lianto, Priscilia
Zhang, Yani
Che, Huilian
Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease
title Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease
title_full Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease
title_fullStr Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease
title_full_unstemmed Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease
title_short Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease
title_sort signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease
topic Current Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676061/
https://www.ncbi.nlm.nih.gov/pubmed/31384583
http://dx.doi.org/10.5415/apallergy.2019.9.e28
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