Antitumor Activity of 1,18-Octadecanedioic Acid-Paclitaxel Complexed with Human Serum Albumin

[Image: see text] We describe the design, synthesis, and antitumor activity of an 18 carbon α,ω-dicarboxylic acid monoconjugated via an ester linkage to paclitaxel (PTX). This 1,18-octadecanedioic acid-PTX (ODDA-PTX) prodrug readily forms a noncovalent complex with human serum albumin (HSA). Preserv...

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Detalles Bibliográficos
Autores principales: Callmann, Cassandra E., LeGuyader, Clare L. M., Burton, Spencer T., Thompson, Matthew P., Hennis, Robert, Barback, Christopher, Henriksen, Niel M., Chan, Warren C., Jaremko, Matt J., Yang, Jin, Garcia, Arnold, Burkart, Michael D., Gilson, Michael K., Momper, Jeremiah D., Bertin, Paul A., Gianneschi, Nathan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676409/
https://www.ncbi.nlm.nih.gov/pubmed/31317744
http://dx.doi.org/10.1021/jacs.9b04272

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