High expression of CD47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis

CD47 functions as a dominant anti-engulfment signal on tumour cells and is overexpressed in various malignant tumours. However, the expression and functional significance of CD47 in triple-negative breast cancer (TNBC) is not completely understood. In the present study, CD47 was demonstrated to be o...

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Autores principales: Yuan, Jingping, Shi, Xuehui, Chen, Chuang, He, Huihua, Liu, Lin, Wu, Juan, Yan, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676440/
https://www.ncbi.nlm.nih.gov/pubmed/31452802
http://dx.doi.org/10.3892/ol.2019.10618
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author Yuan, Jingping
Shi, Xuehui
Chen, Chuang
He, Huihua
Liu, Lin
Wu, Juan
Yan, Honglin
author_facet Yuan, Jingping
Shi, Xuehui
Chen, Chuang
He, Huihua
Liu, Lin
Wu, Juan
Yan, Honglin
author_sort Yuan, Jingping
collection PubMed
description CD47 functions as a dominant anti-engulfment signal on tumour cells and is overexpressed in various malignant tumours. However, the expression and functional significance of CD47 in triple-negative breast cancer (TNBC) is not completely understood. In the present study, CD47 was demonstrated to be overexpressed in TNBC solid tumours. Moreover, increased CD47 expression was significantly associated with an advanced tumour-node-metastasis stage, lymph node involvement and recurrence. Moreover, CD47 was an unfavourable and independent prognostic factor for 5-year disease-free survival in patients with TNBC. In addition, the expression of CD47 was associated with several markers of epithelial-mesenchymal transition (EMT). The present study was the first to demonstrate an association between increased expression of CD47 with EMT and poor prognosis of TNBC. Thus, CD47 may be a potential prognostic biomarker and therapeutic target for TNBC.
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spelling pubmed-66764402019-08-26 High expression of CD47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis Yuan, Jingping Shi, Xuehui Chen, Chuang He, Huihua Liu, Lin Wu, Juan Yan, Honglin Oncol Lett Articles CD47 functions as a dominant anti-engulfment signal on tumour cells and is overexpressed in various malignant tumours. However, the expression and functional significance of CD47 in triple-negative breast cancer (TNBC) is not completely understood. In the present study, CD47 was demonstrated to be overexpressed in TNBC solid tumours. Moreover, increased CD47 expression was significantly associated with an advanced tumour-node-metastasis stage, lymph node involvement and recurrence. Moreover, CD47 was an unfavourable and independent prognostic factor for 5-year disease-free survival in patients with TNBC. In addition, the expression of CD47 was associated with several markers of epithelial-mesenchymal transition (EMT). The present study was the first to demonstrate an association between increased expression of CD47 with EMT and poor prognosis of TNBC. Thus, CD47 may be a potential prognostic biomarker and therapeutic target for TNBC. D.A. Spandidos 2019-09 2019-07-15 /pmc/articles/PMC6676440/ /pubmed/31452802 http://dx.doi.org/10.3892/ol.2019.10618 Text en Copyright: © Yuan et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Yuan, Jingping
Shi, Xuehui
Chen, Chuang
He, Huihua
Liu, Lin
Wu, Juan
Yan, Honglin
High expression of CD47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis
title High expression of CD47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis
title_full High expression of CD47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis
title_fullStr High expression of CD47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis
title_full_unstemmed High expression of CD47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis
title_short High expression of CD47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis
title_sort high expression of cd47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676440/
https://www.ncbi.nlm.nih.gov/pubmed/31452802
http://dx.doi.org/10.3892/ol.2019.10618
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