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Prevalence of positive chronic kidney Disease screening in professional male long haul drivers at risk of cardiovascular Disease in Lagos, Nigeria: a cross-section study

BACKGROUND: Professional drivers are known to be at high risk for cardiovascular disease (CVD) on account of the higher prevalence co-occurring risk factors they harbour. Chronic kidney disease (CKD) and CVD share similar risk factors. Both impact each other adversely. The renal profile of professio...

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Autores principales: Amadi, Casmir E., Mbakwem, Amam C., Kushimo, Oyewole A., Ajuluchukwu, Jayne N., Akinkunmi, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676515/
https://www.ncbi.nlm.nih.gov/pubmed/31370832
http://dx.doi.org/10.1186/s12889-019-7328-6
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author Amadi, Casmir E.
Mbakwem, Amam C.
Kushimo, Oyewole A.
Ajuluchukwu, Jayne N.
Akinkunmi, Michael
author_facet Amadi, Casmir E.
Mbakwem, Amam C.
Kushimo, Oyewole A.
Ajuluchukwu, Jayne N.
Akinkunmi, Michael
author_sort Amadi, Casmir E.
collection PubMed
description BACKGROUND: Professional drivers are known to be at high risk for cardiovascular disease (CVD) on account of the higher prevalence co-occurring risk factors they harbour. Chronic kidney disease (CKD) and CVD share similar risk factors. Both impact each other adversely. The renal profile of professional drivers in Nigeria is not well characterised. We decided to study the prevalence of positive CKD screening amongst professional male long distance drivers in Lagos, Southwest Nigeria so as to quantify the burden and its predictors. METHODS: Two hundred and ninety-three drivers were recruited. Details of their socio-demographic characteristics were obtained. Their anthropometric indices, blood pressure, fasting plasma blood glucose and lipid profile were measured. Serum creatinine was measured and estimated glomerular filtration rate, eGFR, was calculated with Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Urinary Albumin Creatinine Ratio (UACR) was determined. A 10 year CVD risk of the subjects was calculated with the Framingham Risk Score (FRS). RESULTS: Mean age of the study population was 44.8 + 9.7 years. The prevalence of alcohol use and smoking were 71.0 and 19.5% respectively. One hundred and twenty-one (62.8%) of the subjects were either overweight or obese while 70(24.1%) had abdominal obesity. The prevalence of hypertension and diabetes were 39.7 and 13.9% respectively. Prevalence of CKD by eGFR< 60 ml/min/1.73m(2) or UACR > 30 mg/g was 51.7% (95% CI; 46.0–57.5). The odds for CKD increased with lower HDL-c levels; OR 3.5 (95% CI, 1.1–11.2; p = 0.03) and longer duration of professional driving > 20 years; OR 2.4(95% CI, 1.5–4.0). CONCLUSION: Professional male long distance drivers in addition to having very high prevalence of clustering of both CVD and CKD risk factors have a significant burden of asymptomatic CKD. UACR appears to be an earlier marker of CKD in this population. Health awareness promotion and aggressive risk factor reduction are advocated as ways to reduce this burden.
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spelling pubmed-66765152019-08-06 Prevalence of positive chronic kidney Disease screening in professional male long haul drivers at risk of cardiovascular Disease in Lagos, Nigeria: a cross-section study Amadi, Casmir E. Mbakwem, Amam C. Kushimo, Oyewole A. Ajuluchukwu, Jayne N. Akinkunmi, Michael BMC Public Health Research Article BACKGROUND: Professional drivers are known to be at high risk for cardiovascular disease (CVD) on account of the higher prevalence co-occurring risk factors they harbour. Chronic kidney disease (CKD) and CVD share similar risk factors. Both impact each other adversely. The renal profile of professional drivers in Nigeria is not well characterised. We decided to study the prevalence of positive CKD screening amongst professional male long distance drivers in Lagos, Southwest Nigeria so as to quantify the burden and its predictors. METHODS: Two hundred and ninety-three drivers were recruited. Details of their socio-demographic characteristics were obtained. Their anthropometric indices, blood pressure, fasting plasma blood glucose and lipid profile were measured. Serum creatinine was measured and estimated glomerular filtration rate, eGFR, was calculated with Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Urinary Albumin Creatinine Ratio (UACR) was determined. A 10 year CVD risk of the subjects was calculated with the Framingham Risk Score (FRS). RESULTS: Mean age of the study population was 44.8 + 9.7 years. The prevalence of alcohol use and smoking were 71.0 and 19.5% respectively. One hundred and twenty-one (62.8%) of the subjects were either overweight or obese while 70(24.1%) had abdominal obesity. The prevalence of hypertension and diabetes were 39.7 and 13.9% respectively. Prevalence of CKD by eGFR< 60 ml/min/1.73m(2) or UACR > 30 mg/g was 51.7% (95% CI; 46.0–57.5). The odds for CKD increased with lower HDL-c levels; OR 3.5 (95% CI, 1.1–11.2; p = 0.03) and longer duration of professional driving > 20 years; OR 2.4(95% CI, 1.5–4.0). CONCLUSION: Professional male long distance drivers in addition to having very high prevalence of clustering of both CVD and CKD risk factors have a significant burden of asymptomatic CKD. UACR appears to be an earlier marker of CKD in this population. Health awareness promotion and aggressive risk factor reduction are advocated as ways to reduce this burden. BioMed Central 2019-08-01 /pmc/articles/PMC6676515/ /pubmed/31370832 http://dx.doi.org/10.1186/s12889-019-7328-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Amadi, Casmir E.
Mbakwem, Amam C.
Kushimo, Oyewole A.
Ajuluchukwu, Jayne N.
Akinkunmi, Michael
Prevalence of positive chronic kidney Disease screening in professional male long haul drivers at risk of cardiovascular Disease in Lagos, Nigeria: a cross-section study
title Prevalence of positive chronic kidney Disease screening in professional male long haul drivers at risk of cardiovascular Disease in Lagos, Nigeria: a cross-section study
title_full Prevalence of positive chronic kidney Disease screening in professional male long haul drivers at risk of cardiovascular Disease in Lagos, Nigeria: a cross-section study
title_fullStr Prevalence of positive chronic kidney Disease screening in professional male long haul drivers at risk of cardiovascular Disease in Lagos, Nigeria: a cross-section study
title_full_unstemmed Prevalence of positive chronic kidney Disease screening in professional male long haul drivers at risk of cardiovascular Disease in Lagos, Nigeria: a cross-section study
title_short Prevalence of positive chronic kidney Disease screening in professional male long haul drivers at risk of cardiovascular Disease in Lagos, Nigeria: a cross-section study
title_sort prevalence of positive chronic kidney disease screening in professional male long haul drivers at risk of cardiovascular disease in lagos, nigeria: a cross-section study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676515/
https://www.ncbi.nlm.nih.gov/pubmed/31370832
http://dx.doi.org/10.1186/s12889-019-7328-6
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