A statistical and biological response to an informatics appraisal of healthy aging gene signatures

Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below. ELECTRONIC SUPPLEMENTARY MATERIAL: The online vers...

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Autores principales: Timmons, James A., Gallagher, Iain J., Sood, Sanjana, Phillips, Bethan, Crossland, Hannah, Howard, Robert, Kraus, William E., Atherton, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676519/
https://www.ncbi.nlm.nih.gov/pubmed/31375147
http://dx.doi.org/10.1186/s13059-019-1734-z
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author Timmons, James A.
Gallagher, Iain J.
Sood, Sanjana
Phillips, Bethan
Crossland, Hannah
Howard, Robert
Kraus, William E.
Atherton, Philip J.
author_facet Timmons, James A.
Gallagher, Iain J.
Sood, Sanjana
Phillips, Bethan
Crossland, Hannah
Howard, Robert
Kraus, William E.
Atherton, Philip J.
author_sort Timmons, James A.
collection PubMed
description Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13059-019-1734-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-66765192019-08-06 A statistical and biological response to an informatics appraisal of healthy aging gene signatures Timmons, James A. Gallagher, Iain J. Sood, Sanjana Phillips, Bethan Crossland, Hannah Howard, Robert Kraus, William E. Atherton, Philip J. Genome Biol Correspondence Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13059-019-1734-z) contains supplementary material, which is available to authorized users. BioMed Central 2019-08-02 /pmc/articles/PMC6676519/ /pubmed/31375147 http://dx.doi.org/10.1186/s13059-019-1734-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Correspondence
Timmons, James A.
Gallagher, Iain J.
Sood, Sanjana
Phillips, Bethan
Crossland, Hannah
Howard, Robert
Kraus, William E.
Atherton, Philip J.
A statistical and biological response to an informatics appraisal of healthy aging gene signatures
title A statistical and biological response to an informatics appraisal of healthy aging gene signatures
title_full A statistical and biological response to an informatics appraisal of healthy aging gene signatures
title_fullStr A statistical and biological response to an informatics appraisal of healthy aging gene signatures
title_full_unstemmed A statistical and biological response to an informatics appraisal of healthy aging gene signatures
title_short A statistical and biological response to an informatics appraisal of healthy aging gene signatures
title_sort statistical and biological response to an informatics appraisal of healthy aging gene signatures
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676519/
https://www.ncbi.nlm.nih.gov/pubmed/31375147
http://dx.doi.org/10.1186/s13059-019-1734-z
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