Placenta-specific epimutation at H19-DMR among common pregnancy complications: its frequency and effect on the expression patterns of H19 and IGF2

BACKGROUND: H19 and IGF2 genes are imprinted and involved in regulating fetal and placental growth. The H19 differentially methylated region (DMR) is paternally methylated and maternally unmethylated and regulates the imprinted expression of H19 and IGF2. Epimutation at the H19-DMR in humans results...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Yuko, Tayama, Chiharu, Tomikawa, Junko, Akaishi, Rina, Kamura, Hiromi, Matsuoka, Kentaro, Wake, Norio, Minakami, Hisanori, Kato, Kiyoko, Yamada, Takahiro, Nakabayashi, Kazuhiko, Hata, Kenichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676526/
https://www.ncbi.nlm.nih.gov/pubmed/31370882
http://dx.doi.org/10.1186/s13148-019-0712-3

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