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Modelling cholera transmission dynamics in the presence of limited resources

OBJECTIVES: We study the transmission dynamics of cholera in the presence of limited resources, a common feature of the developing world. The model is used to gain insight into the impact of available resources of the health care system on the spread and control of the disease. A deterministic model...

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Autores principales: Nyabadza, Farai, Aduamah, Jennifer Mawunyo, Mushanyu, Josiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676578/
https://www.ncbi.nlm.nih.gov/pubmed/31370867
http://dx.doi.org/10.1186/s13104-019-4504-9
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author Nyabadza, Farai
Aduamah, Jennifer Mawunyo
Mushanyu, Josiah
author_facet Nyabadza, Farai
Aduamah, Jennifer Mawunyo
Mushanyu, Josiah
author_sort Nyabadza, Farai
collection PubMed
description OBJECTIVES: We study the transmission dynamics of cholera in the presence of limited resources, a common feature of the developing world. The model is used to gain insight into the impact of available resources of the health care system on the spread and control of the disease. A deterministic model that includes a nonlinear recovery rate is formulated and rigorously analyzed. Limited treatment is described by inclusion of a special treatment function. Center manifold theory is used to show that the model exhibits the phenomenon of backward bifurcation. Matlab has been used to carry out numerical simulations to support theoretical findings. RESULTS: The model analysis shows that the disease free steady state is locally stable when the threshold [Formula: see text] . It is also shown that the model has multiple equilibria and the model exhibits the phenomenon of backward bifurcation whose implications to cholera infection are discussed. The results are useful for the public health planning in resource allocation for the control of cholera transmission.
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spelling pubmed-66765782019-08-06 Modelling cholera transmission dynamics in the presence of limited resources Nyabadza, Farai Aduamah, Jennifer Mawunyo Mushanyu, Josiah BMC Res Notes Research Note OBJECTIVES: We study the transmission dynamics of cholera in the presence of limited resources, a common feature of the developing world. The model is used to gain insight into the impact of available resources of the health care system on the spread and control of the disease. A deterministic model that includes a nonlinear recovery rate is formulated and rigorously analyzed. Limited treatment is described by inclusion of a special treatment function. Center manifold theory is used to show that the model exhibits the phenomenon of backward bifurcation. Matlab has been used to carry out numerical simulations to support theoretical findings. RESULTS: The model analysis shows that the disease free steady state is locally stable when the threshold [Formula: see text] . It is also shown that the model has multiple equilibria and the model exhibits the phenomenon of backward bifurcation whose implications to cholera infection are discussed. The results are useful for the public health planning in resource allocation for the control of cholera transmission. BioMed Central 2019-08-01 /pmc/articles/PMC6676578/ /pubmed/31370867 http://dx.doi.org/10.1186/s13104-019-4504-9 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Nyabadza, Farai
Aduamah, Jennifer Mawunyo
Mushanyu, Josiah
Modelling cholera transmission dynamics in the presence of limited resources
title Modelling cholera transmission dynamics in the presence of limited resources
title_full Modelling cholera transmission dynamics in the presence of limited resources
title_fullStr Modelling cholera transmission dynamics in the presence of limited resources
title_full_unstemmed Modelling cholera transmission dynamics in the presence of limited resources
title_short Modelling cholera transmission dynamics in the presence of limited resources
title_sort modelling cholera transmission dynamics in the presence of limited resources
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676578/
https://www.ncbi.nlm.nih.gov/pubmed/31370867
http://dx.doi.org/10.1186/s13104-019-4504-9
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