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Peyronie's Disease is common in poorly controlled diabetics but is not associated with the Metabolic Syndrome
PURPOSE: The purpose of the study is to investigate if metabolic syndrome (MS) and other comorbidities are associated with Peyronie's disease (PD). METHODS: A total of 1833 patients retrospectively investigated and divided into two groups: Group A – PD patients (n = 319) and Group B – non-PD pa...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676820/ https://www.ncbi.nlm.nih.gov/pubmed/31413501 http://dx.doi.org/10.4103/UA.UA_164_18 |
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author | Habous, Mohamad Malkawi, Ibraheem Han, Esther Farag, Mohammed Muir, Gordon Abdelwahab, Osama Nassar, Mohammed Mahmoud, Saad Santucci, Richard Binsaleh, Saleh |
author_facet | Habous, Mohamad Malkawi, Ibraheem Han, Esther Farag, Mohammed Muir, Gordon Abdelwahab, Osama Nassar, Mohammed Mahmoud, Saad Santucci, Richard Binsaleh, Saleh |
author_sort | Habous, Mohamad |
collection | PubMed |
description | PURPOSE: The purpose of the study is to investigate if metabolic syndrome (MS) and other comorbidities are associated with Peyronie's disease (PD). METHODS: A total of 1833 patients retrospectively investigated and divided into two groups: Group A – PD patients (n = 319) and Group B – non-PD patients (n = 1303). The two groups were fully evaluated for diabetes mellitus (DM) with the glycated hemoglobin (HbA1c), hypertension (HTN), dyslipidemia (DL), obesity by measuring body mass index, total testosterone (T), penile vascular circulation measuring Peak systolic velocity (PSV) as indicator of arterial supply, end-diastolic velocity (EDV) as indicator of venous output, and finally, smoking. RESULTS: The presence of diabetes was significantly correlated with PD (P = 0.005). Patients with diabetes had a 7% higher incidence of PD. However, patients with the highest HbA1c level of >8.5 had an increased odds ratio of 1.6 (P = 0.025, confidence interval [CI] =1.061–2.459) of having PD. Increased age was significantly correlated with PD (P = 0.025). For each year of life, the likelihood of having PD increases by an odds ratio of 1.019, or 2% per year (P = 0.001, CI = 1.004–1.027). Unexpectedly, DL (P = 0.006) and smoking (P = 0.041) were associated with lower incidences of PD. Patients with DL or smoking had a 5%–7% lower incidence of PD with an odds ratio of 0.6 (P = 0.006, CI = 0.410–0.864). HTN (P = 0.621) and the total number of comorbidities (P = 0.436) were not correlated with PD. Mean serum T values were statistically (P = 0.43) but not clinically significant among patients with Peyronie's versus patients without Peyronie's (4.62 vs. 4.38 ng/ml). Neither low PSV (Fisher's exact test P = 0.912) nor abnormal EDV (Fisher's exact test P = 0.775) was correlated with the finding of PD. CONCLUSIONS: While MS was not associated with PD, diabetes, particularly poorly controlled diabetes, was associated with an increased rate. Further research into the interaction of PD and metabolic disease is warranted. |
format | Online Article Text |
id | pubmed-6676820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-66768202019-08-14 Peyronie's Disease is common in poorly controlled diabetics but is not associated with the Metabolic Syndrome Habous, Mohamad Malkawi, Ibraheem Han, Esther Farag, Mohammed Muir, Gordon Abdelwahab, Osama Nassar, Mohammed Mahmoud, Saad Santucci, Richard Binsaleh, Saleh Urol Ann Original Article PURPOSE: The purpose of the study is to investigate if metabolic syndrome (MS) and other comorbidities are associated with Peyronie's disease (PD). METHODS: A total of 1833 patients retrospectively investigated and divided into two groups: Group A – PD patients (n = 319) and Group B – non-PD patients (n = 1303). The two groups were fully evaluated for diabetes mellitus (DM) with the glycated hemoglobin (HbA1c), hypertension (HTN), dyslipidemia (DL), obesity by measuring body mass index, total testosterone (T), penile vascular circulation measuring Peak systolic velocity (PSV) as indicator of arterial supply, end-diastolic velocity (EDV) as indicator of venous output, and finally, smoking. RESULTS: The presence of diabetes was significantly correlated with PD (P = 0.005). Patients with diabetes had a 7% higher incidence of PD. However, patients with the highest HbA1c level of >8.5 had an increased odds ratio of 1.6 (P = 0.025, confidence interval [CI] =1.061–2.459) of having PD. Increased age was significantly correlated with PD (P = 0.025). For each year of life, the likelihood of having PD increases by an odds ratio of 1.019, or 2% per year (P = 0.001, CI = 1.004–1.027). Unexpectedly, DL (P = 0.006) and smoking (P = 0.041) were associated with lower incidences of PD. Patients with DL or smoking had a 5%–7% lower incidence of PD with an odds ratio of 0.6 (P = 0.006, CI = 0.410–0.864). HTN (P = 0.621) and the total number of comorbidities (P = 0.436) were not correlated with PD. Mean serum T values were statistically (P = 0.43) but not clinically significant among patients with Peyronie's versus patients without Peyronie's (4.62 vs. 4.38 ng/ml). Neither low PSV (Fisher's exact test P = 0.912) nor abnormal EDV (Fisher's exact test P = 0.775) was correlated with the finding of PD. CONCLUSIONS: While MS was not associated with PD, diabetes, particularly poorly controlled diabetes, was associated with an increased rate. Further research into the interaction of PD and metabolic disease is warranted. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6676820/ /pubmed/31413501 http://dx.doi.org/10.4103/UA.UA_164_18 Text en Copyright: © 2019 Urology Annals http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Habous, Mohamad Malkawi, Ibraheem Han, Esther Farag, Mohammed Muir, Gordon Abdelwahab, Osama Nassar, Mohammed Mahmoud, Saad Santucci, Richard Binsaleh, Saleh Peyronie's Disease is common in poorly controlled diabetics but is not associated with the Metabolic Syndrome |
title | Peyronie's Disease is common in poorly controlled diabetics but is not associated with the Metabolic Syndrome |
title_full | Peyronie's Disease is common in poorly controlled diabetics but is not associated with the Metabolic Syndrome |
title_fullStr | Peyronie's Disease is common in poorly controlled diabetics but is not associated with the Metabolic Syndrome |
title_full_unstemmed | Peyronie's Disease is common in poorly controlled diabetics but is not associated with the Metabolic Syndrome |
title_short | Peyronie's Disease is common in poorly controlled diabetics but is not associated with the Metabolic Syndrome |
title_sort | peyronie's disease is common in poorly controlled diabetics but is not associated with the metabolic syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676820/ https://www.ncbi.nlm.nih.gov/pubmed/31413501 http://dx.doi.org/10.4103/UA.UA_164_18 |
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