HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response

Host encounters with viruses lead to an innate immune response that must be rapid and broadly targeted but also tightly regulated to avoid the detrimental effects of unregulated interferon expression. Viral stimulation of host negative regulatory mechanisms is an alternate method of suppressing the...

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Detalles Bibliográficos
Autores principales: Joyce, Michael A., Berry-Wynne, Karyn M., dos Santos, Theodore, Addison, William R., McFarlane, Nicola, Hobman, Tom, Tyrrell, D. Lorne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677295/
https://www.ncbi.nlm.nih.gov/pubmed/31374104
http://dx.doi.org/10.1371/journal.ppat.1007949

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