Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience

Pediatric patients frequently present with illnesses strongly suggesting infection, but without a clearly identified etiology. Our center has recently added a commercially available plasma metagenomic sequencing assay to its available diagnostic testing. Our experience with the first 100 tests sugge...

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Detalles Bibliográficos
Autores principales: Rossoff, Jenna, Chaudhury, Sonali, Soneji, Maulin, Patel, Sameer J, Kwon, Soyang, Armstrong, Amy, Muller, William J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677669/
https://www.ncbi.nlm.nih.gov/pubmed/31375834
http://dx.doi.org/10.1093/ofid/ofz327
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author Rossoff, Jenna
Chaudhury, Sonali
Soneji, Maulin
Patel, Sameer J
Kwon, Soyang
Armstrong, Amy
Muller, William J
author_facet Rossoff, Jenna
Chaudhury, Sonali
Soneji, Maulin
Patel, Sameer J
Kwon, Soyang
Armstrong, Amy
Muller, William J
author_sort Rossoff, Jenna
collection PubMed
description Pediatric patients frequently present with illnesses strongly suggesting infection, but without a clearly identified etiology. Our center has recently added a commercially available plasma metagenomic sequencing assay to its available diagnostic testing. Our experience with the first 100 tests suggests that this technology has good clinical performance with >90% sensitivity.
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spelling pubmed-66776692019-08-07 Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience Rossoff, Jenna Chaudhury, Sonali Soneji, Maulin Patel, Sameer J Kwon, Soyang Armstrong, Amy Muller, William J Open Forum Infect Dis Brief Report Pediatric patients frequently present with illnesses strongly suggesting infection, but without a clearly identified etiology. Our center has recently added a commercially available plasma metagenomic sequencing assay to its available diagnostic testing. Our experience with the first 100 tests suggests that this technology has good clinical performance with >90% sensitivity. Oxford University Press 2019-07-12 /pmc/articles/PMC6677669/ /pubmed/31375834 http://dx.doi.org/10.1093/ofid/ofz327 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Rossoff, Jenna
Chaudhury, Sonali
Soneji, Maulin
Patel, Sameer J
Kwon, Soyang
Armstrong, Amy
Muller, William J
Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience
title Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience
title_full Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience
title_fullStr Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience
title_full_unstemmed Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience
title_short Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience
title_sort noninvasive diagnosis of infection using plasma next-generation sequencing: a single-center experience
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677669/
https://www.ncbi.nlm.nih.gov/pubmed/31375834
http://dx.doi.org/10.1093/ofid/ofz327
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