A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific l...

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Detalles Bibliográficos
Autores principales: van der Lee, Sven J., Knol, Maria J., Chauhan, Ganesh, Satizabal, Claudia L., Smith, Albert Vernon, Hofer, Edith, Bis, Joshua C., Hibar, Derrek P., Hilal, Saima, van den Akker, Erik B., Arfanakis, Konstantinos, Bernard, Manon, Yanek, Lisa R., Amin, Najaf, Crivello, Fabrice, Cheung, Josh W., Harris, Tamara B., Saba, Yasaman, Lopez, Oscar L., Li, Shuo, van der Grond, Jeroen, Yu, Lei, Paus, Tomas, Roshchupkin, Gennady V., Amouyel, Philippe, Jahanshad, Neda, Taylor, Kent D., Yang, Qiong, Mathias, Rasika A., Boehringer, Stefan, Mazoyer, Bernard, Rice, Ken, Cheng, Ching Yu, Maillard, Pauline, van Heemst, Diana, Wong, Tien Yin, Niessen, Wiro J., Beiser, Alexa S., Beekman, Marian, Zhao, Wanting, Nyquist, Paul A., Chen, Christopher, Launer, Lenore J., Psaty, Bruce M., Ikram, M. Kamran, Vernooij, Meike W., Schmidt, Helena, Pausova, Zdenka, Becker, Diane M., De Jager, Philip L., Thompson, Paul M., van Duijn, Cornelia M., Bennett, David A., Slagboom, P. Eline, Schmidt, Reinhold, Longstreth, W. T., Ikram, M. Arfan, Seshadri, Sudha, Debette, Stéphanie, Gudnason, Vilmundur, Adams, Hieab H. H., DeCarli, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677735/
https://www.ncbi.nlm.nih.gov/pubmed/31396565
http://dx.doi.org/10.1038/s42003-019-0537-9

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