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The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia
Extreme weather events frequency and scale are altered due to climate change. Symbiosis between corals and their endosymbiotic-dinoflagellates (Symbiodinium) is susceptible to these events and can lead to what is known as bleaching. However, there is evidence for coral adaptive plasticity in the rol...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677750/ https://www.ncbi.nlm.nih.gov/pubmed/31396562 http://dx.doi.org/10.1038/s42003-019-0543-y |
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author | Weizman, Eviatar Levy, Oren |
author_facet | Weizman, Eviatar Levy, Oren |
author_sort | Weizman, Eviatar |
collection | PubMed |
description | Extreme weather events frequency and scale are altered due to climate change. Symbiosis between corals and their endosymbiotic-dinoflagellates (Symbiodinium) is susceptible to these events and can lead to what is known as bleaching. However, there is evidence for coral adaptive plasticity in the role of epigenetic that have acclimated to high-temperature environments. We have implemented ATAC-seq and RNA-seq to study the cnidarian-dinoflagellate model Exaptasia pallida (Aiptasia) and expose the role of chromatin-dynamics in response to thermal-stress. We have identified 1309 genomic sites that change their accessibility in response to thermal changes. Moreover, apo-symbiotic Aiptasia accessible sites were enriched with NFAT, ATF4, GATA3, SOX14, and PAX3 motifs and expressed genes related to immunological pathways. Symbiotic Aiptasia accessible sites were enriched with NKx3-1, HNF4A, IRF4 motifs and expressed genes related to oxidative-stress pathways. Our work opens a new path towards understanding thermal-stress gene regulation in association with gene activity and chromatin-dynamics. |
format | Online Article Text |
id | pubmed-6677750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-66777502019-08-08 The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia Weizman, Eviatar Levy, Oren Commun Biol Article Extreme weather events frequency and scale are altered due to climate change. Symbiosis between corals and their endosymbiotic-dinoflagellates (Symbiodinium) is susceptible to these events and can lead to what is known as bleaching. However, there is evidence for coral adaptive plasticity in the role of epigenetic that have acclimated to high-temperature environments. We have implemented ATAC-seq and RNA-seq to study the cnidarian-dinoflagellate model Exaptasia pallida (Aiptasia) and expose the role of chromatin-dynamics in response to thermal-stress. We have identified 1309 genomic sites that change their accessibility in response to thermal changes. Moreover, apo-symbiotic Aiptasia accessible sites were enriched with NFAT, ATF4, GATA3, SOX14, and PAX3 motifs and expressed genes related to immunological pathways. Symbiotic Aiptasia accessible sites were enriched with NKx3-1, HNF4A, IRF4 motifs and expressed genes related to oxidative-stress pathways. Our work opens a new path towards understanding thermal-stress gene regulation in association with gene activity and chromatin-dynamics. Nature Publishing Group UK 2019-08-02 /pmc/articles/PMC6677750/ /pubmed/31396562 http://dx.doi.org/10.1038/s42003-019-0543-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Weizman, Eviatar Levy, Oren The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia |
title | The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia |
title_full | The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia |
title_fullStr | The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia |
title_full_unstemmed | The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia |
title_short | The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia |
title_sort | role of chromatin dynamics under global warming response in the symbiotic coral model aiptasia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677750/ https://www.ncbi.nlm.nih.gov/pubmed/31396562 http://dx.doi.org/10.1038/s42003-019-0543-y |
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