Quantitative Profiling of Oncometabolites in Frozen and Formalin-Fixed Paraffin-Embedded Tissue Specimens by Liquid Chromatography Coupled with Tandem Mass Spectrometry

Given the implications of oncometabolites [succinate, fumarate, and 2-hydroxyglutarate (2HG)] in cancer pathogenesis and therapeutics, quantitative determination of their tissue levels has significant diagnostic, prognostic, and therapeutic values. Here, we developed and validated a multiplex liquid...

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Detalles Bibliográficos
Autores principales: Bao, Xun, Wu, Jianmei, Shuch, Brian, LoRusso, Patricia, Bindra, Ranjit S., Li, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677826/
https://www.ncbi.nlm.nih.gov/pubmed/31375752
http://dx.doi.org/10.1038/s41598-019-47669-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677826/
https://www.ncbi.nlm.nih.gov/pubmed/31375752
http://dx.doi.org/10.1038/s41598-019-47669-5

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